Allopurinol riboside
Allopurinol riboside structure
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Common Name | Allopurinol riboside | ||
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| CAS Number | 16220-07-8 | Molecular Weight | 268.22600 | |
| Density | 2.08g/cm3 | Boiling Point | 570.9ºC at 760mmHg | |
| Molecular Formula | C10H12N4O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 299ºC | |
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Activity of inosine analogs against Pneumocystis carinii in culture.
Antimicrob. Agents Chemother. 30(1) , 181-3, (1986) Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 micrograms/ml... |
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A tissue culture system for the growth of several species of Leishmania: growth kinetics and drug sensitivities.
Am. J. Trop. Med. Hyg. 38(2) , 304-7, (1988) We have developed a simple in vitro method of infecting a continuous human macrophage cell line (U937) with promastigotes of several species of Leishmania. These include L. braziliensis braziliensis, L. b. panamensis, L. donovani, L. mexicana mexicana, L. m. ... |
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On the metabolism of allopurinol. Formation of allopurinol-1-riboside in purine nucleoside phosphorylase deficiency.
Biochem. Pharmacol. 32(14) , 2167-74, (1983) Allopurinol-1-riboside, a major metabolite of allopurinol, is commonly thought to be directly synthesized by purine nucleoside phosphorylase (PNP) in vivo. As this enzyme is otherwise believed to function in vivo primarily in the direction of nucleoside break... |
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Efficacy of pyrazolopyrimidine ribonucleosides against Trypanosoma cruzi: studies in vitro and in vivo with sensitive and resistant strains.
J. Infect. Dis. 150(4) , 602-8, (1984) Strains of Trypanosoma cruzi differ in their susceptibilities to and metabolism of pyrazolopyrimidines. Allopurinol riboside can control but not eliminate infections with a sensitive strain in both tissue culture and mice. Formycin B, which proved to be great... |
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Pharmacokinetics and metabolism of allopurinol riboside.
Clin. Pharmacol. Ther. 49(5) , 506-14, (1991) There are no safe and effective oral drugs to treat leishmaniasis and Chagas' disease. The safety, pharmacokinetics, and metabolism of single and multiple oral doses of allopurinol riboside, an investigational antiparasitic agent, were evaluated in a randomiz... |
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In vitro antileishmanial activity of inhibitors of steroid biosynthesis and combinations of antileishmanial agents.
J. Parasitol. 73(3) , 671-3, (1987)
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Mechanisms of action of pyrazolopyrimidines in Leishmania donovani.
J. Biol. Chem. 261(20) , 9412-5, (1986) We investigated the antileishmanial actions of the pyrazolopyrimidines allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine), thiopurinol (4-thiopyrazolo[3,4-d]pyrimidine), and aminopurinol (4-aminopyrazolo[3,4-d]pyrimidine). These compounds affect several metabol... |
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Biochemical genetic analysis of formycin B action in Leishmania donovani.
J. Biol. Chem. 259(12) , 7637-43, (1984) Formycin B is cytotoxic toward Leishmania and is a potential chemotherapeutic agent for leishmaniasis. In order to determine the mechanism of action of formycin B, we have isolated and characterized clonal populations of formycin B-resistant Leishmania donova... |
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The effect of allopurinol ribonucleoside and formycin B on Trypanosoma cruzi infections in mice.
Trans. R. Soc. Trop. Med. Hyg. 79(4) , 517-8, (1985) The anti-Trypanosoma cruzi effect of allopurinol ribonucleoside and formycin B was examined against infections of the sensitive Y and Peru strains in inbred mice, strain DBA/1. Allopurinol ribonucleoside given in the drinking water at doses calculated to be 2... |
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In vitro susceptibility testing of Naegleria fowleri to ketoconazole, BAYn7133, and allopurinol riboside.
J. Parasitol. 70(2) , 317-8, (1984)
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