22-alpha-Hydroxy Cholesterol
22-alpha-Hydroxy Cholesterol structure
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Common Name | 22-alpha-Hydroxy Cholesterol | ||
|---|---|---|---|---|
| CAS Number | 17954-98-2 | Molecular Weight | 402.65 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 513.1±23.0 °C at 760 mmHg | |
| Molecular Formula | C27H46O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 213.5±17.2 °C | |
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Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.
Gynecol. Oncol. 135(2) , 333-41, (2014) Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT ass... |
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HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells.
Toxicol. Appl. Pharmacol. 282(1) , 20-9, (2015) Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD disturbs basal and human chorionic gonadotropin (hCG)-induced st... |
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Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.
Biol. Reprod. 86(1) , 1-12, (2012) In fish, like in other vertebrates, luteinizing hormone (Lh) is an essential hormone for the completion of oocyte maturation. In salmonid fish (i.e., salmon and trout), oocyte maturation is induced by Lh through its stimulation of the production of the matura... |
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Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.
Mol. Cell. Endocrinol. 392(1-2) , 173-81, (2014) Recent evidence has shown a role for the serine/threonine protein kinase D (PKD) in the regulation of acute aldosterone secretion upon angiotensin II (AngII) stimulation. However, the mechanism by which AngII activates PKD remains unclear. In this study, usin... |
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A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.
Mol. Cell. Biol. 34(23) , 4257-71, (2014) Steroid hormones regulate essential physiological processes, and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by luteinizing hormone (LH) via its receptor... |
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Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.
Chem. Biol. Interact. 199(3) , 185-91, (2012) Cisplatin (Cs) is a chemotherapeutic agent able to generate reactive oxygen species (ROS) which are linked to several side effects of the drug. Even when it is known that Cs produces Leydig cell dysfunction, it is unknown whether this particular side effect i... |
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Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages.
J. Cell. Biochem. 116 , 2032-8, (2015) The transcription of the ATP-binding cassette transporter A1 (ABCA1) gene, which plays a key anti-atherogenic role, is known to be induced by agonists of liver X receptors (LXRs). LXRs form obligate heterodimers with retinoid X receptors (RXRs) and interact w... |
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Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.
Endocrinology 156(5) , 1750-6, (2015) There is considerable evidence supporting the role of calcium signaling in adrenal regulation of both aldosterone synthase (CYP11B2) and aldosterone production. However, there have been no studies that investigated the role played by the Ca(2+)/calmodulin-dep... |
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A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
Mol. Cell. Endocrinol. 366(1) , 31-7, (2013) The mineralocorticoid aldosterone plays an important role in regulating blood pressure, with excess causing hypertension and exacerbating cardiovascular disease. Previous studies have indicated a role for both phospholipase D (PLD) and protein kinase D (PKD) ... |
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Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages.
FEBS Lett. 589(1) , 52-8, (2015) Dickkopf1 (DKK1), a canonical Wnt/β-catenin pathway antagonist, is closely associated with cardiovascular disease and adipogenesis. We performed an in vitro study to determine whether oxidized low-density lipoprotein (ox-LDL) increased the expression of DKK1 ... |