Latanoprost
Latanoprost structure
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Common Name | Latanoprost | ||
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| CAS Number | 130209-82-4 | Molecular Weight | 432.593 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 583.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H40O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 188.3±23.6 °C | |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits.
Curr. Eye Res. 39(8) , 813-22, (2014) To evaluate the topical instillation of K-115, a selective Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, on intraocular pressure (IOP), ocular distribution, and aqueous humor dynamics in experimental animals.Kinase inhibition by K-115... |
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COX-2 inhibition improves retinal function in rats' ischemic eyes.
J. Ocul. Pharmacol. Ther. 30(8) , 634-41, (2014) Retinal ischemia is a relatively simple model for studies in pharmacological neuroprotective intervention. The role of cyclooxygenase (COX) enzymes in ischemic insult has been variously shown to either increase or decrease ischemic damage. The purpose of this... |
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Regulation of Endothelin-1-Induced Trabecular Meshwork Cell Contractility by Latanoprostene Bunod.
Invest. Ophthalmol. Vis. Sci. 56 , 4108-16, (2015) Previous in vivo studies demonstrated that latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2α receptor agonist, results in greater intraocular pressure (IOP) lowering than latanoprost. The present series of investigations compared the ... |
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Sodium hyaluronate decreases ocular surface toxicity induced by benzalkonium chloride-preserved latanoprost: an in vivo study.
Invest. Ophthalmol. Vis. Sci. 54(5) , 3385-93, (2013) To investigate the effects of sodium hyaluronate (SH) on ocular surface toxicity induced by benzalkonium chloride (BAC)-preserved latanoprost.Twenty-one white rabbits (42 eyes) were randomly divided into three groups. The control group was untreated. The two ... |
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Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.
PLoS ONE 7(9) , e45273, (2012) Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail. In our experiments, prostaglandin (PG)F(2α)... |
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Extended latanoprost release from commercial contact lenses: in vitro studies using corneal models.
PLoS ONE 9(9) , e106653, (2014) In this study, we compared, for the first time, the release of a 432 kDa prostaglandin F2a analogue drug, Latanoprost, from commercially available contact lenses using in vitro models with corneal epithelial cells. Conventional polyHEMA-based and silicone hyd... |
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Comparison of the Progression Rates of the Superior, Inferior, and Both Hemifield Defects in Normal-Tension Glaucoma Patients
Am. J. Ophthalmol. 154(6) , 958-968.e1, (2012) Purpose To investigate the progression rates of superior and inferior hemifield defects and each hemifield in bihemifield defects in normal-tension glaucoma patients and to compare the progression rates of each hemifield between groups in eyes with similar ba... |
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Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension.
Acta Biomater. 10(10) , 4360-6, (2014) Glaucoma is an irreversible ocular disease that may lead to progressive visual field loss and eventually to blindness with inadequately controlled intraocular pressure (IOP). Latanoprost is one of the most potent ocular hypotensive compounds, the current firs... |
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Are generic topical prostanoids the way forward in the care of glaucoma patients? - Yes.
Eye (Lond.) 27(9) , 999-1001, (2013)
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