(4-Aminophenyl)acetic acid

(4-Aminophenyl)acetic acid Structure
(4-Aminophenyl)acetic acid structure
Common Name (4-Aminophenyl)acetic acid
CAS Number 1197-55-3 Molecular Weight 151.163
Density 1.3±0.1 g/cm3 Boiling Point 344.0±17.0 °C at 760 mmHg
Molecular Formula C8H9NO2 Melting Point 201 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 161.9±20.9 °C

4-aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1.

J. Physiol. 512 ( Pt 3) , 629-34, (1998)

1. 4-Aminomethylbenzoic acid, a molecule which mimics the special configuration of a dipeptide, competitively inhibits peptide influx in both Xenopus Laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles. 2. This...

Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.

Acta. Pharm. 56(3) , 273-84, (2006)

Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral d...

Peptide mimics as substrates for the intestinal peptide transporter.

J. Biol. Chem. 273(1) , 20-2, (1998)

4-Aminophenylacetic acid (4-APAA), a peptide mimic lacking a peptide bond, has been shown to interact with a proton-coupled oligopeptide transporter using a number of different experimental approaches. In addition to inhibiting transport of labeled peptides, ...

p-Aminophenylacetic acid-mediated synthesis of monodispersed titanium oxide hybrid microspheres in ethanol solution.

J. Colloid. Interface Sci. 338(2) , 468-73, (2009)

Monodispersed TiO2 hybrid microspheres were prepared via the hydrolysis of titanium isopropoxide (TTIP) in ethanol solution containing p-aminophenylacetic acid (APA). The effects of the APA:TTIP molar ratio, water content, reaction time and reaction temperatu...

Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA.

Dig. Dis. Sci. 50(3) , 565-73, (2005)

A new compound, APAZA, consisting of a molecule of 5-aminosalicylic acid linked to one molecule of 4-aminophenylacetic acid by an azo bond, was testedfor its ability to inhibit acute colitis in rats caused by Clostridium difficile toxin A. When administered c...