Flubendazole
Flubendazole structure
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Common Name | Flubendazole | ||
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| CAS Number | 31430-15-6 | Molecular Weight | 313.283 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H12FN3O3 | Melting Point | 290°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.
Expert Rev. Anti. Infect. Ther. 9(5) , 497-501, (2011)
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Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions.
Int. J. Pharm. 453(2) , 343-50, (2013) This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole were selected as model ingredients, whereas microfluidizatio... |
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Transfer of flubendazole and tylosin from feed at cross-contamination levels to various poultry matrices.
Poult. Sci. 91(9) , 2351-60, (2012) Residues of veterinary drugs and feed additives used extensively in animal husbandry are sometimes found in edible matrices. In this study, broilers received experimental feed, containing either flubendazole or tylosin, at cross-contamination levels of 2.5%, ... |
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The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics.
Parasitology 139(10) , 1309-16, (2012) Haemonchus contortus is one of the most pathogenic parasites of small ruminants (e.g. sheep and goat). The treatment of haemonchosis is complicated because of recurrent resistance of H. contortus to common anthelmintics. The aim of this study was to compare t... |
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A pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep.
Acta Trop. 127(3) , 216-25, (2013) Cyst echinococcosis (CE) is a zoonotic disease caused by the larval stage of the Echinococcus granulosus helminth parasite. The work reported here aimed to compare the efficacy of albendazole (ABZ) and flubendazole (FLBZ) against CE in naturally infected shee... |
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Comparison of single and split-dose flubendazole treatment for the nematode parasite Trichostrongylus tenuis in experimentally infected grey partridges Perdix perdix.
Parasitology 139(13) , 1780-3, (2012) Different therapeutic regimes using flubendazole for the treatment of Trichostrongylus tenuis infection in experimentally infected grey partridges Perdix perdix were examined. Flubendazole dosages of 4, 8 and 20 mg/kg were administered orally as a single dose... |
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30-yr course and favorable outcome of alveolar echinococcosis despite multiple metastatic organ involvement in a non-immune suppressed patient.
Ann. Clin. Microbiol. Antimicrob. 12 , 1, (2013) We report the 30-yr history of a well-documented human case of alveolar echinococcosis, with a lung lesion at presentation followed by the discovery of a liver lesion, both removed by surgery. Subsequently, within the 13 years following diagnosis, metastases ... |
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Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of Trichinella spiralis infection.
Chemotherapy 58(4) , 295-8, (2012) Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic compound. The parent FLBZ is metabolized to its reduced (R-FLBZ) and hydrolyzed (H-FLBZ) metabolites. There are no data on the potential nematodicidal activity of R-FLBZ, the main plasma metab... |
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Effects of the benzimidazole anthelmintic drug flubendazole on rat embryos in vitro.
Reprod. Toxicol. 36 , 78-87, (2013) Filarial diseases affect millions of people in poverty-stricken areas. In 2011, an investigation of the potential of flubendazole as a safe, highly efficacious, and field-usable macrofilaricidal drug was begun by Drug for Neglected Diseases initiative. As par... |
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Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution.
BMC Vet. Res. 8 , 71, (2012) Flubendazole (FLBZ) is a poor water solubility broad-spectrum BZD methylcarbamate anthelmintic compound. Cyclodextrins (CDs) are usually used to increase aqueous solubility of poor hydrosoluble compounds. The comparative in vitro aqueous solubility of FLBZ an... |