Pyridoxal 5'-phosphate monohydrate
Pyridoxal 5'-phosphate monohydrate structure
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Common Name | Pyridoxal 5'-phosphate monohydrate | ||
|---|---|---|---|---|
| CAS Number | 41468-25-1 | Molecular Weight | 265.157 | |
| Density | N/A | Boiling Point | 565.7ºC at 760 mmHg | |
| Molecular Formula | C8H12NO7P | Melting Point | 140-143 °C(lit.) | |
| MSDS | USA | Flash Point | 296ºC | |
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Epidermal axonal swellings in painful and painless diabetic peripheral neuropathy.
Muscle Nerve 51(4) , 505-13, (2015) The pathophysiology of neuropathic pain (NeP) in diabetic peripheral neuropathy (DPN) is unclear. A potential pathological feature associated with intraepidermal nerve fiber density (IENFD) loss in DPN is axonal swellings.We determined the prevalence of intra... |
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Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.
J. Neuropathol. Exp. Neurol. 74 , 1093-118, (2015) Despite effective viral suppression through combined antiretroviral therapy (cART), approximately half of HIV-positive individuals have HIV-associated neurocognitive disorders (HAND). Studies of antiretroviral-treated patients have revealed persistent white m... |
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Four different synthetic peptides of proteolipid protein induce a distinct antibody response in MP4-induced experimental autoimmune encephalomyelitis.
Clin. Immunol. 159 , 93-106, (2015) Here we studied the autoantibody specificity elicited by proteolipid protein (PLP) in MP4-induced experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis (MS). In C57BL/6 (B6) mice, antibodies were induced by immunization with one of th... |
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Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.
Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014) We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vita... |
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pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules.
Int. J. Pharm. 478(2) , 496-503, (2015) Hydrogels synthesized from poly(l-lysine isophthalamide) (PLP) crosslinked with l-lysine methyl ester were investigated as drug delivery systems for a wide size range of molecules (0.3-2000kDa). PLP is an anionic, pseudo-peptidic polymer that is an ideal hydr... |
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Fluorescent probes for tracking the transfer of iron-sulfur cluster and other metal cofactors in biosynthetic reaction pathways.
J. Am. Chem. Soc. 137(1) , 390-8, (2015) Iron-sulfur (Fe-S) clusters are protein cofactors that are constructed and delivered to target proteins by elaborate biosynthetic machinery. Mechanistic insights into these processes have been limited by the lack of sensitive probes for tracking Fe-S cluster ... |
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Hydrogen sulfide production from subgingival plaque samples.
Anaerobe 35 , 21-7, (2015) Periodontitis is a polymicrobial anaerobe infection. Little is known about the dysbiotic microbiota and the role of bacterial metabolites in the disease process. It is suggested that the production of certain waste products in the proteolytic metabolism may w... |
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Translational control of myelin basic protein expression by ERK2 MAP kinase regulates timely remyelination in the adult brain.
J. Neurosci. 35 , 7850-65, (2015) Successful myelin repair in the adult CNS requires the robust and timely production of myelin proteins to generate new myelin sheaths. The underlying regulatory mechanisms and complex molecular basis of myelin regeneration, however, remain poorly understood. ... |
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A new target region for changing the substrate specificity of amine transaminases.
Sci. Rep. 5 , 10753, (2015) (R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the production of (R)-amine compounds in a strict stereospecific manner. An improved R-ATA, ATA-117-Rd11, was successfully engineered for the manufacture of sitagliptin, a widely u... |
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An optimized coupled assay for quantifying diaminopimelate decarboxylase activity.
Biochimie 115 , 78-85, (2015) Diaminopimelate decarboxylase (DAPDC) catalyzes the conversion of meso-DAP to lysine and carbon dioxide in the final step of the diaminopimelate (DAP) pathway in plants and bacteria. Given its absence in humans, DAPDC is a promising antibacterial target, part... |