L-798106
L-798106 structure
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Common Name | L-798106 | ||
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| CAS Number | 244101-02-8 | Molecular Weight | 536.43700 | |
| Density | 1.425±0.06 g/cm3(Predicted) | Boiling Point | N/A | |
| Molecular Formula | C27H22BrNO4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Angiogenesis in the primate ovulatory follicle is stimulated by luteinizing hormone via prostaglandin E2.
Biol. Reprod. 92(1) , 15, (2015) Rapid angiogenesis occurs as the ovulatory follicle is transformed into the corpus luteum. To determine if luteinizing hormone (LH)-stimulated prostaglandin E2 (PGE2) regulates angiogenesis in the ovulatory follicle, cynomolgus macaques received gonadotropins... |
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Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells.
Biol. Chem. 396(2) , 153-62, (2015) We analyzed signaling mechanisms for prostaglandin E2 (PGE2) production following activation of proteinase-activated receptor-1 (PAR1), a thrombin receptor, in preosteoblastic MC3T3-E1 cells. PAR1 stimulation caused PGE2 release, an effect suppressed by inhib... |
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6-Substituted 9-fluoroquino[3,2-b]benzo[1,4]thiazines display strong antiproliferative and antitumor properties.
Eur. J. Med. Chem. 89 , 411-20, (2014) 6-Substituted 9-fluoroquino[3,2-b]benzo[1,4]thiazines - a new type of tetracyclic azaphenothiazines-were obtained from of 6H-9-fluoroquinobenzothiazine by the introduction of appropriate substituents to the thiazine nitrogen atom (alkyl, aminoalkyl, amidoalky... |
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Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production.
J. Cell Physiol. 230(4) , 863-74, (2014) The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a reactive oxygen species-sensitive multiprotein complex that regulates IL-1β maturation via caspase-1. It also plays an important role in the pathogenesis of inflammation-related disease. Cycl... |
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Deficiency of female sex hormones augments PGE2 and CGRP levels within midbrain periaqueductal gray.
J. Neurol. Sci. 346(1-2) , 107-11, (2014) The midbrain periaqueductal gray (PAG) is a substantial component of the descending modulatory network to control on nociceptive transmission and autonomic functions. Also, accumulated evidence has suggested that the PAG plays a crucial role in regulating mig... |
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Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells.
Drug Metab. Dispos. 42(12) , 2077-86, (2014) Prostaglandin (PG) E2, a major product of cyclooxygenase (COX)-2, acts as an immunomodulator at the maternal-fetal interface during pregnancy. It exerts biologic function through interaction with E-prostanoid (EP) receptors localized to the placenta. The acti... |
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EP₃ receptors mediate PGE₂-induced hypothalamic paraventricular nucleus excitation and sympathetic activation.
Am. J. Physiol. Heart Circ. Physiol. 301(4) , H1559-69, (2011) Prostaglandin E(2) (PGE(2)), an important mediator of the inflammatory response, acts centrally to elicit sympathetic excitation. PGE(2) acts on at least four E-class prostanoid (EP) receptors known as EP(1), EP(2), EP(3), and EP(4). Since PGE(2) production w... |
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Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney.
Am. J. Physiol. Renal Physiol. 303(3) , F449-57, (2012) Cyclooxygenase-2 (COX-2) is constitutively expressed and highly regulated in the thick ascending limb (TAL). As COX-2 inhibitors (Coxibs) increase COX-2 expression, we tested the hypothesis that a negative feedback mechanism involving PGE(2) EP3 receptors reg... |
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Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP.
Br. J. Pharmacol. 173 , 319-31, (2015) Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to play a critical role in host defence, although the role of PGE2 ,... |
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Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
J. Periodontol. 84(12) , 1847-57, (2013) During periodontitis and orthodontic tooth movement, periodontal vasculature is severely impaired, leading to a hypoxic microenvironment of periodontal cells. However, the impact of hypoxia on periodontal cells is poorly defined. The present study investigate... |