fibronectin type iii connecting segment fragment 1-25
fibronectin type iii connecting segment fragment 1-25 structure
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Common Name | fibronectin type iii connecting segment fragment 1-25 | ||
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| CAS Number | 107978-77-8 | Molecular Weight | 2732.05000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C123H195N31O39 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats.
Endocr. J. 55(2) , 373-9, (2008) To compare the effects of postprandial hypertriglyceridemia and postprandial hyperglycemia on monocyte adhesion to endothelial cells, we investigated the effects of twice-daily standard diet (5% fat) and high-fat diet (30% fat) for 3 weeks on monocyte adhesio... |
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Fibronectin-alpha4beta1 integrin interactions modulate p42/44 MAPK phosphorylation in steatotic liver cold ischemia-reperfusion injury.
Transplant. Proc. 37(1) , 432-4, (2005) We investigated the effects of the connecting segment-1 (CS1) peptide, which blocks fibronectin (FN)-alpha4beta1 integrin interactions upon cell signaling, leukocyte migration, and secretion of proinflammatory cytokines, in a well-established steatotic rat li... |
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Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta.
Arterioscler. Thromb. Vasc. Biol. 26(10) , 2275-80, (2006) The aim of this study was to elucidate the effect of repetitive fluctuations in blood glucose concentrations on monocyte adhesion to the aortic endothelium.Nonobese type 2 diabetes, Goto-Kakizaki (GK) rats were fed twice daily to induce repetitive postprandia... |
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Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion.
Br. J. Pharmacol. 126(8) , 1751-60, (1999) 1. Small, N- to C-terminal cyclized peptides containing the leucyl-aspartyl-valine (LDV) motif from fibronectin connecting segment-1 (CS-1) have been investigated for their effects on the adhesion of human T-lymphoblastic leukaemia cells (MOLT-4) to human pla... |
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alpha4 integrin in islet allograft rejection.
Transplantation 71(11) , 1549-55, (2001) Adhesion molecules are involved in multiple steps of the continuum of allograft rejection. We studied the effects of blockade of the interactions between alpha4 integrin and its ligands, vascular cell adhesion molecule-1 (VCAM-1) and fibronectin, on allograft... |
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T lymphocyte adhesion mechanisms within inflamed human kidney: studies with a Stamper-Woodruff assay.
Am. J. Pathol. 154(2) , 503-14, (1999) Renal inflammatory conditions are characterized by mononuclear cell recruitment to sites of inflammation. We have developed a modified Stamper-Woodruff assay system to analyze mechanisms of functional T cell adhesion to cryostat sections of renal biopsy mater... |
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Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins.
J. Biol. Chem. 273(12) , 6670-8, (1998) Here we show striking differences in conformational regulation among beta1 integrins. Upon manganese stimulation, a beta1 epitope defined by monoclonal antibody (mAb) 9EG7 was induced strongly (on alpha4beta1), moderately (on alpha5beta1), weakly (on alpha2be... |
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A cyclic hexapeptide is a potent antagonist of alpha 4 integrins.
J. Immunol. 158(4) , 1710-8, (1997) The alpha 4 integrins mediate leukocyte adhesion to specific counter-receptors, including vascular cell adhesion molecule-1 (VCAM-1), the fibronectin splice variant containing connecting segment 1 (CS1), and mucosal addressin cell adhesion molecule-1. A serie... |
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Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation.
Biochem. J. 313 ( Pt 3) , 899-908, (1996) Here we describe experiments in which we mutated four of the six integrin alpha 4 subunit cysteine residues that are not present in most other integrin alpha subunits that lack an I domain. In four different types of ligand binding assay we found that optimal... |
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The role of CS1 moiety of fibronectin in VLA mediated haemopoietic progenitor trafficking.
Br. J. Haematol. 97(1) , 15-21, (1997) In vitro the integrin VLA4 mediates the adhesion of haemopoietic progenitors to bone marrow stroma through an interaction with its ligands VCAM-1 and the CS1 moiety of fibronectin. The VLA4/VCAM-1 pathway has been implicated in haemopoietic trafficking in viv... |