mono-Methyl-5-nitroisophthalic acid

mono-Methyl-5-nitroisophthalic acid Structure
mono-Methyl-5-nitroisophthalic acid structure
Common Name mono-Methyl-5-nitroisophthalic acid
CAS Number 1955-46-0 Molecular Weight 225.155
Density 1.5±0.1 g/cm3 Boiling Point 419.7±35.0 °C at 760 mmHg
Molecular Formula C9H7NO6 Melting Point 180-182 °C(lit.)
MSDS Chinese USA Flash Point 207.6±25.9 °C

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.

Bioorg. Med. Chem. Lett. 17(12) , 3378-83, (2007)

The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.