D-Allylglycine
D-Allylglycine structure
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Common Name | D-Allylglycine | ||
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| CAS Number | 54594-06-8 | Molecular Weight | 115.131 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 230.9±33.0 °C at 760 mmHg | |
| Molecular Formula | C5H9NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 93.5±25.4 °C | |
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Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.
J. Med. Chem. 52 , 5093-107, (2009) Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid group little substitution is tolerated. We have solved thi... |
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In vivo neurochemical evidence that newly synthesised GABA activates GABA(B), but not GABA(A), receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats.
Neuropharmacology 62 , 907-913, (2012) GABA released from accumbal GABAergic interneurons plays an inhibitory role in the regulation of dopamine efflux through GABA(B) and GABA(A) receptors located on accumbal dopaminergic nerve endings. The cytosolic newly synthesised GABA alters vesicular GABA l... |
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Cyclic opioid peptide agonists and antagonists obtained via ring-closing metathesis.
Chem. Biol. Drug Des. 74 , 329-334, (2009) The opioid peptide H-Tyr-c[D-Cys-Phe-Phe-Cys]NH(2) cyclized via a methylene dithiother is a potent and selective mu opioid agonist (Przydial M.J. et al., J Peptide Res, 66, 2005, 255). Dicarba analogues of this peptide with Tyr, 2',6'-dimethyltyrosine (Dmt), ... |
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Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic.
J. Psychopharmacol. 22 , 642-652, (2008) Panic patients are vulnerable to induction of panic attacks by sub-threshold interoceptive stimuli such as intravenous (i.v.) sodium lactate infusions. Facilitation of serotonergic signaling with selective serotonin reuptake inhibitors can suppress anxiety an... |
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Metabolism of allylglycine and cis-crotylglycine by Pseudomonas putida (arvilla) mt-2 harboring a TOL plasmid.
J. Bacteriol. 148 , 72-82, (1981) Spontaneous mutants which acquired the ability to utilize d-allylglycine (d-2-amino-4-pentenoic acid) and dl-cis-crotylglycine (dl-2-amino-cis-4-hexenoic acid) but not l-allylglycine or dl-trans-crotylglycine could be readily isolated from Pseudomonas putida ... |