Cilostamide
Cilostamide structure
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Common Name | Cilostamide | ||
|---|---|---|---|---|
| CAS Number | 68550-75-4 | Molecular Weight | 342.432 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 594.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H26N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 313.2±30.1 °C | |
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Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.
J. Pharmacol. Exp. Ther. 350(3) , 681-90, (2014) We previously found a negative inotropic (NIR) and positive lusitropic response (LR) to C-type natriuretic peptide (CNP) in the failing heart ventricle. In this study, we investigated and compared the functional responses to the natriuretic peptides (NPs), br... |
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Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation.
FASEB J. 29 , 3458-71, (2015) Many different neurotransmitters and hormones control intracellular signaling by regulating the production of the second messenger cAMP. The function of the broadly expressed adenylyl cyclases (ACs) 5 and 6 is regulated by either stimulatory or inhibitory G p... |
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Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling.
Cardiovasc. Res. 107 , 89-97, (2015) Lymphatic vessel dysfunction is an emerging component of metabolic diseases and can lead to tissue lipid accumulation, dyslipidaemia, and oedema. While lymph leakage has been implicated in obesity and hypercholesterolaemia, whether similar lymphatic dysfuncti... |
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In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.
Nat. Commun. 6 , 6965, (2015) 3',5'-cyclic adenosine monophosphate (cAMP) is an ubiquitous second messenger that regulates physiological functions by acting in distinct subcellular microdomains. Although several targeted cAMP biosensors are developed and used in single cells, it is unclea... |
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Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.
Br. J. Pharmacol. 171(23) , 5361-75, (2014) This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, following heart failure (HF).Twenty-two weeks after proximal aor... |
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Follicle-Stimulating Hormone Increases Gap Junctional Communication Between Somatic and Germ-Line Follicular Compartments During Murine Oogenesis.
Biol. Reprod. 93 , 47, (2015) Germ cells develop in intimate contact and communication with somatic cells of the gonad. In female mammals, oocyte development depends crucially on gap junctions that couple it to the surrounding somatic granulosa cells of the follicle, yet the mechanisms th... |
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The gene expression signature of anagrelide provides an insight into its mechanism of action and uncovers new regulators of megakaryopoiesis.
J. Thromb. Haemost. 13 , 1103-12, (2015) Anagrelide is a cytoreductive agent used to lower platelet counts in essential thrombocythemia. Although the drug has been known to selectively inhibit megakaryopoiesis for many years, the molecular mechanism accounting for this activity is still unclear.To a... |
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Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Mol. Carcinog. 54(3) , 203-15, (2015) Aggressive dissemination and metastasis of pancreatic ductal adenocarcinoma (PDAC) results in poor prognosis and marked lethality. Rho monomeric G protein levels are increased in pancreatic cancer tissue. As the mechanisms underlying PDAC malignancy are littl... |
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Angiotensin II type 2 receptor regulates ROMK-like K⁺ channel activity in the renal cortical collecting duct during high dietary K⁺ adaptation.
Am. J. Physiol. Renal Physiol. 307(7) , F833-43, (2014) The kidney adjusts K⁺ excretion to match intake in part by regulation of the activity of apical K⁺ secretory channels, including renal outer medullary K⁺ (ROMK)-like K⁺ channels, in the cortical collecting duct (CCD). ANG II inhibits ROMK channels via the ANG... |
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QRFP-43 inhibits lipolysis by preventing ligand-induced complex formation between perilipin A, caveolin-1, the catalytic subunit of protein kinase and hormone-sensitive lipase in 3T3-L1 adipocytes.
Biochim. Biophys. Acta 1851(5) , 657-66, (2015) QRFP (RFamide) peptides are neuropeptides involved in food intake and adiposity regulation in rodents. We have previously shown that QRFP-43 (43RFa) and QRFP-26 (26RFa) inhibited isoproterenol (ISO)-induced lipolysis in adipocytes. However, the antilipolytic ... |