1-Aminocyclohexanecarboxylic acid
1-Aminocyclohexanecarboxylic acid structure
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Common Name | 1-Aminocyclohexanecarboxylic acid | ||
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| CAS Number | 2756-85-6 | Molecular Weight | 143.184 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 272.3±23.0 °C at 760 mmHg | |
| Molecular Formula | C7H13NO2 | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 118.5±22.6 °C | |
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Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.
J. Med. Chem. 52 , 5093-107, (2009) Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid group little substitution is tolerated. We have solved thi... |
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Application of 1-aminocyclohexane carboxylic acid to protein nanostructure computer design.
J. Chem. Inf. Model. 48(2) , 333-43, (2008) Conformationally restricted amino acids are promising candidates to serve as basic pieces in redesigned protein motifs which constitute the basic modules in synthetic nanoconstructs. Here we study the ability of constrained cyclic amino acid 1-aminocyclohexan... |
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Influence of 1-aminocyclohexane-1-carboxylic acid in position 2 or 3 of AVP and its analogues on their pharmacological properties.
J. Pept. Res. 62(2) , 70-7, (2003) In this study we describe the synthesis and some pharmacological properties of seven new analogues of arginine vasopressin (AVP) substituted in position 2 or 3 with 1-aminocyclohexane-1-carboxylic acid (Acc). All peptides were tested for the pressor, antidiur... |
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Highly potent 1-aminocyclohexane-1-carboxylic acid substituted V2 agonists of arginine vasopressin.
J. Med. Chem. 47(24) , 6020-4, (2004) The synthesis and some pharmacological properties of two sets of analogues, one consisting of six peptides with 1-aminocyclohexane-1-carboxylic acid (Acc) in position 2 and the other with the amino acid in position 3, have been described. All the peptides wer... |
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Nitroxyl peptides as catalysts of enantioselective oxidations.
Chemistry 8(1) , 84-93, (2002) The achiral, nitroxyl-containing alpha-amino acid TOAC (TOAC = 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid), in combination with the chiral alpha-amino acid C(alpha)-methyl valine [(alphaMe)Val], was used to prepare short peptides (from di-... |
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Inhibition of neutral amino acid transport across the human blood-brain barrier by phenylalanine.
J. Neurochem. 64(3) , 1252-7, (1995) The delivery of large neutral amino acids (LNAAs) to brain across the blood-brain barrier (BBB) is mediated by the L-type neutral amino acid transporter present in the membranes of the brain capillary endothelial cell. In experimental animals, the L-system tr... |
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Raman and surface-enhanced Raman spectroscopy investigation of vasopressin analogues containing 1-aminocyclohexane-1-carboxylic acid residue.
Biopolymers 83(2) , 193-203, (2006) In this work, Raman spectroscopy (RS) was employed to characterize molecular structures of [Arg8]vasopressin (AVP) and its [Acc2,D-Arg8]AVP, [Acc3]AVP, and [Cpa1, Acc3]AVP analogues. The RS band assignments have been proposed. To determine the mechanism of ad... |
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A highly active chemotactic peptide analog incorporating the unusual residue 1-aminocyclohexanecarboxylic acid at position 2.
Biochem. Biophys. Res. Commun. 128(1) , 339-44, (1985) Analogs of chemotactic peptides (Formyl-Met-X-Phe-OMe) containing the stereochemically constrained residues alpha-aminoisobutyric acid (Aib), 1-aminocyclopentanecarboxylic acid (Acc5) and 1-aminocyclohexanecarboxylic acid (Acc6) at position 2 are compared wit... |
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New bradykinin analogues modified in the C-terminal part with sterically restricted 1-aminocyclohexane-1-carboxylic acid.
J. Med. Chem. 48(25) , 8055-9, (2005) In the present work, a sterically constrained noncoded amino acid, 1-aminocyclohexane-1-carboxylic acid (Acc), was substituted in position 8 of the peptide chain of bradykinin (BK) and position 6, 7, or 8 of its B2 receptor antagonist [D-Arg0,Hyp3,Thi,(5,8)D-... |
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Blood-brain barrier transport of 1-aminocyclohexanecarboxylic acid, a nonmetabolizable amino acid for in vivo studies of brain transport.
J. Neurochem. 50(4) , 1220-6, (1988) Regional transport of 1-aminocyclohexanecarboxylic acid (ACHC), a nonmetabolizable amino acid, across the blood-brain barrier was studied in pentobarbital-anesthetized rats using an in situ brain perfusion technique. The concentration dependence of influx was... |