CCK-4
CCK-4 structure
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Common Name | CCK-4 | ||
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| CAS Number | 1947-37-1 | Molecular Weight | 596.70 | |
| Density | 1.341g/cm3 | Boiling Point | 1159.2ºC at 760mmHg | |
| Molecular Formula | C29H36N6O6S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 654.8ºC | |
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Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer.
PLoS ONE 10 , e0123768, (2015) Biomarkers and novel therapeutic targets are urgently needed in colorectal cancer (CRC). The pseudo tyrosine kinase receptor 7 (PTK7) is involved in planar cell polarity and it is deregulated in various malignancies, including CRC. Yet, little is known about ... |
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CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
J. Mol. Neurosci. 56 , 663-72, (2015) Cholecystokinin (CCK) receptors are G-protein coupled receptors (GPCR) which are present on lung cancer cells. CCK-8 stimulates the proliferation of lung cancer cells, whereas the CCK2R receptor antagonist CI-988 inhibits proliferation. GPCR for some gastroin... |
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Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting.
Eur. J. Med. Chem. 45(2) , 423-9, (2010) The goal of this study is to design new (99m)Tc-radiolabelled shortened CCK derivatives that might be suitable for the molecular imaging of cholecystokinin-2 receptors (CCK2-R), these receptors being over-expressed in a number of neuroendocrine tumors such as... |
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[Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome].
Eksp. Klin. Farmakol. 74(10) , 7-11, (2011) The effects of GB-115 dipeptide, a retroanalog of endogenous CCK-4, on the behavioral indices in "elevated plus maze" (EPM) test and on the content of biogenic amines in the brain structures after discontinuation of a chronic administration of benzodiazepine ... |
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Solid-phase extraction-field-amplified sample injection coupled with CE-ESI-MS for online pre-concentration and quantitative analysis of brain-gut peptides.
Electrophoresis 32(20) , 2823-9, (2011) In order to improve the sensitivity of CE-ESI-MS for the analysis of brain-gut peptides, a solid-phase extraction combined with field-amplified sample injection was used for the pre-concentration of the brain-gut peptides. Compared with the conventional press... |
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Benzodiazepines counteract rostral anterior cingulate cortex activation induced by cholecystokinin-tetrapeptide in humans.
Biol. Psychiatry 73(4) , 337-44, (2013) Benzodiazepines modulate γ-aminobutyric acid type A (GABA(A)) receptors throughout the brain. However, it is not fully understood which brain regions within anxiety-related brain circuits are really responsible for their anxiolytic effects and how these regio... |
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Distinct panicogenic activity of sodium lactate and cholecystokinin tetrapeptide in patients with panic disorder.
Curr. Pharm. Des. 18(35) , 5619-26, (2012) The validity of experimentally induced panic attacks as a model to study the pathophysiology of panic disorder has been questioned. Unspecific, unpleasant and aversive effects as well as specific patterns of psychovegetative symptoms pointing to different sub... |
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Solid-state stability studies of cholecystokinin (CCK-4) peptide under nonisothermal conditions using thermal analysis, chromatography and mass spectrometry.
Eur. J. Pharm. Sci. 39(4) , 263-71, (2010) The solid-state stability of cholecystokinin (CCK-4) peptide under nonisothermal conditions was studied by differential scanning calorimetry (DSC), chromatography and mass spectrometry, identifying and schematizing the degradation products. To model the degra... |
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Cholecystokinin action on layer 6b neurons in somatosensory cortex.
Brain Res. 1282 , 10-9, (2009) Layer 6b in neocortex is a distinct sublamina at the ventral portion of layer 6. Corticothalamic projections arise from 6b neurons, but few studies have examined the functional properties of these cells. In the present study we examined the actions of cholecy... |
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Associations between personality traits and CCK-4-induced panic attacks in healthy volunteers.
Psychiatry Res. 178(2) , 342-7, (2010) In this study we examined how personality disposition may affect the response to cholecystokinin tetrapeptide (CCK-4; 50 microg) challenge in healthy volunteers (n=105). Personality traits were assessed with the Swedish universities Scales of Personality (SSP... |