SB269970 HCl
SB269970 HCl structure
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Common Name | SB269970 HCl | ||
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| CAS Number | 261901-57-9 | Molecular Weight | 388.95200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H29ClN2O3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
J. Med. Chem. 43(3) , 342-345, (2000)
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Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.
Br. J. Pharmacol. 130(3) , 539-48, (2000) The novel 5-HT(7) receptor antagonist, SB-269970-A, potently displaced [(3)H]-5-CT from human 5-HT(7(a)) (pK(i) 8.9+/-0.1) and 5-HT(7) receptors in guinea-pig cortex (pK(i) 8.3+/-0.2). 5-CT stimulated adenylyl cyclase activity in 5-HT(7(a))/HEK293 membranes (... |
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[(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.
Br. J. Pharmacol. 130(2) , 409-17, (2000) Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT binding. [(... |
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8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents.
Eur. J. Pharmacol. 487(1-3) , 125-32, (2004) Studies using selective drugs and knockout mice have demonstrated that the 5-HT(7) receptor plays an instrumental role in serotonin-induced hypothermia. There is also evidence supporting an involvement of the 5-HT(1A) receptor, although mainly from studies us... |
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Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.
Br. J. Pharmacol. 165(7) , 2191-202, (2012) Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the resistance arteries. Tryptamine interacts with trace amine-associated receptors (TAARs) and because of its structural similarity... |
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Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats.
PLoS ONE 8(6) , e66695, (2013) A wide body of evidence suggests that 5-HT7 receptors are implicated in a variety of central nervous system functions, including control of learning and memory processes. According to recent preclinical data, the selective blockade of these receptors may be a... |
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Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus.
Pharmacol. Rep. 64(2) , 256-65, (2012) SB 269970, a 5-HT(7) receptor antagonist may produce a faster antidepressant-like effect in animal models, than do antidepressant drugs, e.g., imipramine. The present work was aimed at examining the effect of single and repeated (14 days) administration of SB... |