4-Pyrimidinol
4-Pyrimidinol structure
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Common Name | 4-Pyrimidinol | ||
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| CAS Number | 4562-27-0 | Molecular Weight | 96.087 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 227.2±13.0 °C at 760 mmHg | |
| Molecular Formula | C4H4N2O | Melting Point | 163-167ºC | |
| MSDS | USA | Flash Point | 91.2±19.8 °C | |
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Gas-phase tautomeric equilibrium of 4-hydroxypyrimidine with its ketonic forms: a free jet millimeterwave spectroscopy study.
J. Am. Chem. Soc. 129(19) , 6287-90, (2007) 4-Hydroxypyrimidine (4HP) has two conformational forms (the hydroxyl hydrogen cis or trans with respect to the adjacent nitrogen), which are in tautomeric equilibrium with two ketonic forms, 4-pyrimidinone (4PO) and 6-pyrimidinone (6PO). We have investigated ... |
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Tautomerism in 4-hydroxypyrimidine, S-methyl-2-thiouracil, and 2-thiouracil.
J. Phys. Chem. A 114(48) , 12725-30, (2010) The keto-enol tautomerism of 4-hydroxypyrimidine and of the related molecules S-methyl-2-thiouracil and 2-thiouracil has been investigated using synchrotron-based techniques. The populations of the constituent tautomers and thermodynamic parameters have been ... |
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Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Bioorg. Med. Chem. 18(10) , 3575-87, (2010) A series of eight N(4)-phenylsubstituted-6-(2,4-dichlorophenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines 8-15 were synthesized as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with varied substitutions in the phenyl ring of the 4-an... |
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Kinetic isotope effects and electron transfer in the reduction of xanthine oxidoreductase with 4-hydroxypyrimidine. A comparison between oxidase and dehydrogenase forms.
J. Biol. Chem. 272(36) , 22514-25, (1997) Isolated from bovine milk, xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are two interconvertible forms of the same protein, differing in the number of protein cysteines versus cystines. Most differences between XO and XDH are localized to the FAD ce... |