Bepridil hydrochloride
Bepridil hydrochloride structure
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Common Name | Bepridil hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 74764-40-2 | Molecular Weight | 421.01600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H37ClN2O2 | Melting Point | 91 ±2° | |
| MSDS | USA | Flash Point | N/A | |
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Pulsed infrared radiation excites cultured neonatal spiral and vestibular ganglion neurons by modulating mitochondrial calcium cycling.
J. Neurophysiol. 112(6) , 1246-55, (2014) Cochlear implants are currently the most effective solution for profound sensorineural hearing loss, and vestibular prostheses are under development to treat bilateral vestibulopathies. Electrical current spread in these neuroprostheses limits channel indepen... |
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A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.
Nat. Commun. 5 , 5683, (2014) Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies dep... |
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Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.
Drug Metab. Pharmacokinet. 30 , 257-62, (2015) The aims of this study were to clarify whether the ratio of S- to R-flecainide (S/R ratio) in the serum flecainide concentration was associated with the stereoselectivity of flecainide metabolism, and to investigate the effects of the cytochrome P450 (CYP) 2D... |
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Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog.
Pacing Clin. Electrophysiol. 33(8) , 950-9, (2010) Bepridil (a multiple channel blocker) may markedly prolong the QT interval and induce polymorphic ventricular tachyarrhythmias (VTA). We compared the transmural ventricular repolarization characteristics and inducibility of polymorphic VTA after administratio... |
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Repetitive evaluation of fibrillation cycle length predicts the efficacy of bepridil for interruption of long-lasting persistent atrial fibrillation.
Int. Heart J. 52(6) , 353-8, (2011) Although bepridil is effective for conversion of long-lasting persistent atrial fibrillation (AF) to sinus rhythm, it sometimes takes a long time to interrupt AF and there is no feasible index to predict its efficacy.In 60 patients with long-lasting persisten... |
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An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard.
J. Chromatogr. Sci. 49(7) , 519-23, (2011) A modified method for the quantitative determination of bepridil hydrochloride in human plasma is described. This method is unrelated to chemical methods currently in use. The mobile phase is 50 mM phosphate buffer (pH3.0)-methanol-acetonitrile-triethylamine ... |
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Identification of FDA-approved drugs that computationally bind to MDM2.
Chem. Biol. Drug Des. 80(4) , 631-7, (2012) The integrity of the p53 tumor suppressor pathway is compromised in the majority of cancers. In 7% of cancers p53 is inactivated by abnormally high levels of MDM2--an E3 ubiquitin ligase that polyubiquitinates p53, marking it for degradation. MDM2 engages p53... |
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Effectiveness of amiodarone versus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomised trial.
Heart 98(14) , 1067-71, (2012) Pharmacological conversion to sinus rhythm is generally difficult to achieve, particularly in long-lasting persistent atrial fibrillation (AF). The purpose of this study is to compare the effectiveness of two agents, amiodarone and bepridil, in achieving conv... |
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An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome.
Biochim. Biophys. Acta 1828(6) , 1494-502, (2013) The human ether-a-go-go-related gene (hERG) voltage-gated K(+) channels are located in heart cell membranes and hold a unique selectivity filter (SF) amino acid sequence (SVGFG) as compared to other K(+) channels (TVGYG). The hERG provokes the acquired long Q... |
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In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR.
Exp. Parasitol. 128(2) , 111-5, (2011) The need for novel and efficacious drugs against neglected parasitic diseases, such as Leishmaniasis and American Trypanosomiasis, is certainly apparent. In this work, we evaluated the in vitro potential of the calcium channel blocker bepridil against Leishma... |