BIO
BIO structure
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Common Name | BIO | ||
|---|---|---|---|---|
| CAS Number | 667463-62-9 | Molecular Weight | 356.173 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 554.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H10BrN3O2 | Melting Point | 300°C(lit.) | |
| MSDS | USA | Flash Point | 289.0±30.1 °C | |
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Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants.
J. Biol. Chem. 290 , 17228-38, (2015) Leber congenital amaurosis 9 (LCA9) is an autosomal recessive retinal degeneration condition caused by mutations in the NAD(+) biosynthetic enzyme NMNAT1. This condition leads to early blindness but no other consistent deficits have been reported in patients ... |
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Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1.
ChemBioChem. 16 , 1601-7, (2015) A series of 17 new analogues of trypsin inhibitor SFTI-1 were designed and synthesized to obtain matriptase-2 inhibitors. A number of the modified bicyclic peptides displayed much higher affinity towards matriptase-2 than towards the highly homologous matript... |
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Novel recA-Independent Horizontal Gene Transfer in Escherichia coli K-12.
PLoS ONE 10 , e0130813, (2015) In bacteria, mechanisms that incorporate DNA into a genome without strand-transfer proteins such as RecA play a major role in generating novelty by horizontal gene transfer. We describe a new illegitimate recombination event in Escherichia coli K-12: RecA-ind... |
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Changes in the Gene Expression Profiles of the Hypopharyngeal Gland of Worker Honeybees in Association with Worker Behavior and Hormonal Factors.
PLoS ONE 10 , e0130206, (2015) The hypopharyngeal glands (HPGs) of worker honeybees undergo physiological changes along with the age-dependent role change from nursing to foraging: nurse bee HPGs secrete mainly major royal jelly proteins, whereas forager HPGs secrete mainly α-glucosidase I... |
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Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation.
Biochem. J. 468 , 177-90, (2015) The serotonin [5-HT (5-hydroxytryptamine)] transporter (SERT) controls serotonergic neurotransmission in the brain by rapid clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary targets for antidepressants for therapeutic inter... |
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Mechanisms of Fatal Cardiotoxicity following High-Dose Cyclophosphamide Therapy and a Method for Its Prevention.
PLoS ONE 10 , e0131394, (2015) Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly understood cardiotoxic mechanisms of high-dose CY. A rat cardiac myocardial cell line, H9c2, was exposed to CY me... |
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Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine.
Sci. Rep. 5 , 16479, (2015) Enterocytes play an important role in drug absorption and metabolism. However, a widely used enterocyte model, Caco-2 cell, has difficulty in evaluating both drug absorption and metabolism because the expression levels of some drug absorption and metabolism-r... |
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Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model.
Mol. Med. Report. 12 , 4103-8, (2015) Neuropsychological factors have been shown to influence tumor progression and therapeutic response. The present study investigated the effect of the dopamine receptor antagonist thioridazine on murine breast cancer. The anti‑tumor efficacy of thioridazine was... |
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Derivation of embryonic stem cells from Kunming mice IVF blastocyst in feeder- and serum-free condition.
In Vitro Cell. Dev. Biol. Anim. 51 , 541-5, (2015) Kunming mice are widely used in China; however, it is difficult to isolate embryonic stem cells (ESCs) in conventional derivation condition containing feeder cells and serum. 6-Bromoindirubin-3'-oxime (BIO), a glycogen synthase kinase 3 (GSK3) inhibitor, coul... |
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Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts.
Int. J. Nanomedicine 10 , 4691-703, (2015) Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote c... |