Withaferin A
Withaferin A structure
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Common Name | Withaferin A | ||
|---|---|---|---|---|
| CAS Number | 5119-48-2 | Molecular Weight | 470.598 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 680.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C28H38O6 | Melting Point | 252-253ºC | |
| MSDS | Chinese USA | Flash Point | 226.7±25.0 °C | |
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Multi-layer polymeric implants for sustained release of chemopreventives.
Cancer Lett. 326(1) , 33-40, (2012) Poor oral bioavailability limits the use of many chemopreventives in the prevention and treatment of cancer. To overcome this limitation, we report an improvised implant formulation ("coated" implants) using curcumin, individual curcuminoids, withaferin A and... |
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Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells.
Cancer Sci. 104(2) , 143-8, (2013) Withaferin A (WA) is a bioactive compound derived from Withania somnifera. The antitumor activity of WA has been well studied in human cancer models; however, its chemopreventive potential is unclear. In the present study, we used the skin epidermal JB6 P+ ce... |
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Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance.
PLoS ONE 7(11) , e50547, (2012) In the present study, withaferin A (WA), a steroidal lactone with anti-inflammatory and anti-tumor properties, inhibited proteasome activity and induced endoplasmic reticulum (ER) and cytoplasmic HSP accumulation in Xenopus laevis A6 kidney epithelial cells. ... |
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Withaferin-A reduces type I collagen expression in vitro and inhibits development of myocardial fibrosis in vivo.
PLoS ONE 7(8) , e42989, (2012) Type I collagen is the most abundant protein in the human body. Its excessive synthesis results in fibrosis of various organs. Fibrosis is a major medical problem without an existing cure. Excessive synthesis of type I collagen in fibrosis is primarily due to... |
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Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract.
Cancer Immunol. Immunother. 62(11) , 1663-73, (2013) Myeloid cells play a crucial role in tumor progression. The most common tumor-infiltrating myeloid cells are myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAMs). These cells promote tumor growth by their inherent immune suppressive... |
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Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.
Eur. J. Med. Chem. 54 , 499-511, (2012) Six new withanolides (1-6) along with eleven known ones (7-17) were isolated from the leaves of Withania aristata. Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques. Semisynthesis of the minority metab... |
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Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo.
PLoS ONE 7(8) , e41214, (2012) The medicinal plant Withania somnifera has been used for over centuries in Indian Ayurvedic Medicine to treat a wide spectrum of disorders. Withaferin A (WA), a bioactive compound that is isolated from this plant, has anti-inflammatory, immuno-modulatory, ant... |
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Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines.
Biochem. Biophys. Res. Commun. 423(4) , 819-25, (2012) Cisplatin derivatives are used as the mainline treatment of ovarian cancer, despite their severe side effects and development of resistance. We developed a novel combination therapy by combining cisplatin with withaferin A. Treatment of ovarian cancer cell li... |
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Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation.
Tumour Biol. 33(4) , 1179-89, (2012) Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. While effective therapy exists for the primary tumor, there is a lack of effective treatment for metastatic disease currently. Natural withanolide withaferin A (WA) has shown eff... |
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Qualitative and quantitative variations in withanolides and expression of some pathway genes during different stages of morphogenesis in Withania somnifera Dunal.
Protoplasma 250(2) , 539-49, (2013) Withania somnifera Dunal is an important and extensively studied medicinal plant; however, there is no report available that relates withanolide content and its profile in relation to the expression of pathway genes during different morphogenic stages. In thi... |