Bicuculline methiodide
Bicuculline methiodide structure
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Common Name | Bicuculline methiodide | ||
|---|---|---|---|---|
| CAS Number | 40709-69-1 | Molecular Weight | 509.29 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20INO6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging.
Nat. Commun. 5 , 5259, (2014) Calcium imaging is a versatile experimental approach capable of resolving single neurons with single-cell spatial resolution in the brain. Electrophysiological recordings provide high temporal, but limited spatial resolution, because of the geometrical inacce... |
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Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
J. Neurosci. 33(13) , 5867-77, (2013) Although the contribution of postsynaptic mechanisms to long-term synaptic plasticity has been studied extensively, understanding the contribution of presynaptic modifications to this process lags behind, primarily because of a lack of techniques with which t... |
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Effects of nitric oxide synthase blockade on dorsal vagal stimulation-induced pancreatic insulin secretion
Brain Res. 1394 , 62-70, (2011) We and others have previously shown that the dorsal motor nucleus of the vagus (DMV) is involved in regulation of pancreatic exocrine secretion. Many pancreatic preganglionic neurons within the DMV are inhibited by pancreatic secretagogues suggesting that an ... |
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Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation.
J. Neurosci. Methods 192(1) , 110-4, (2010) Transient electrical impulses are conventionally used to elicit physiological responses in excitable tissues. While electrical stimulation has many advantages, it requires an electrode-tissue interface, exhibits relatively low spatial selectivity and always p... |
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An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci.
Physiol. Res. 61(3) , 325-9, (2012) Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP353... |
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Direction-selective circuitry in rat retina develops independently of GABAergic, cholinergic and action potential activity.
PLoS ONE 6(5) , e19477, (2011) The ON-OFF direction selective ganglion cells (DSGCs) in the mammalian retina code image motion by responding much more strongly to movement in one direction. They do so by receiving inhibitory inputs selectively from a particular sector of processes of the o... |
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Ring-shaped neuronal networks: a platform to study persistent activity.
Lab Chip 11(6) , 1081-8, (2011) Persistent activity in the brain is involved in working memory and motor planning. The ability of the brain to hold information 'online' long after an initiating stimulus is a hallmark of brain areas such as the prefrontal cortex. Recurrent network loops such... |
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Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.
Neuroscience 189 , 108-22, (2011) Adult synapsin triple-knockout mice exhibit epilepsy that manifests as generalized tonic-clonic seizures. Because in vitro recordings have shown a reduction in quantal release from inhibitory neurons, an inherent excitation-inhibition imbalance has been hypot... |
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Spiking patterns and their functional implications in the antennal lobe of the tobacco hornworm Manduca sexta.
PLoS ONE 6(8) , e23382, (2011) Bursting as well as tonic firing patterns have been described in various sensory systems. In the olfactory system, spontaneous bursts have been observed in neurons distributed across several synaptic levels, from the periphery, to the olfactory bulb (OB) and ... |
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An abrupt developmental shift in callosal modulation of sleep-related spindle bursts coincides with the emergence of excitatory-inhibitory balance and a reduction of somatosensory cortical plasticity.
Behav. Neurosci. 124(5) , 600-11, (2010) Transecting the corpus callosum of postnatal day (P)1-6 rats disinhibits the production of spindle bursts (SBs) within primary somatosensory cortex (S1), most notably during periods of sleep-related myoclonic twitching. Here we investigated developmental chan... |