Pyren-1-ylmethanol
Pyren-1-ylmethanol structure
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Common Name | Pyren-1-ylmethanol | ||
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| CAS Number | 24463-15-8 | Molecular Weight | 232.27700 | |
| Density | 1.321g/cm3 | Boiling Point | 455.2ºC at 760mmHg | |
| Molecular Formula | C17H12O | Melting Point | 123-126 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 207.5ºC | |
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Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats.
Carcinogenesis 14(11) , 2267-70, (1993) Rat liver cytosolic hydroxysteroid sulfotransferases form highly reactive sulfuric acid esters from some benzylic alcohols, such as 1-hydroxymethylpyrene. In this study we examined the expression of hydroxysteroid sulfotransferase a (STa) in carcinogen-induce... |
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Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons.
Drug Metab. Dispos. 35(10) , 1824-31, (2007) Excretion of mercapturic acids of a xenobiotic is a good indicator for the formation of electrophilic intermediates. However, the route of excretion, urine or feces, is important for usage of a given mercapturic acid as a biomarker in humans. In the present s... |
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1-Sulfooxymethylpyrene is an electrophilic mutagen and ultimate carcinogen of 1-methyl- and 1-hydroxymethylpyrene.
Biochem. Biophys. Res. Commun. 228(1) , 105-9, (1996) 1-Hydroxymethylpyrene and 1-sulfooxymethylpyrene were tested for complete carcinogenic activity by repeated s.c. injection in groups of 12 female Sprague-Dawley rats, respectively. A dose of 0.2 mumol of either 1-sulfooxymethylpyrene or 1-hydroxymethylpyrene ... |
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Activation of 1-hydroxymethylpyrene to an electrophilic and mutagenic metabolite by rat hepatic sulfotransferase activity.
Adv. Exp. Med. Biol. 283 , 383-91, (1991)
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A fluorescent thermometer based on a pyrene-labeled thermoresponsive polymer.
Sensors (Basel.) 10(9) , 7979-90, (2010) Thermoresponsive polymers that undergo a solubility transition by variation of the temperature are important materials for the development of 'smart' materials. In this contribution we exploit the solubility phase transition of poly(methoxy diethylene glycol ... |
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Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium.
Pharmacogenetics 12(9) , 677-89, (2002) Various enzymatically formed sulfuric acid esters are chemically reactive and mutagenic. This metabolic activation pathway is not detected in standard in-vitro mutagenicity test systems. We describe the construction of Salmonella typhimurium TA1538-derived st... |
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Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems.
Chem. Biol. Interact. 109(1-3) , 195-219, (1998) Sulfation is a common final step in the biotransformation of xenobiotics and is traditionally associated with inactivation. However, the sulfate group is electron-withdrawing and may be cleaved off heterolytically in some molecules leading to electrophilic ca... |
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Formation of DNA adducts from 1-hydroxymethylpyrene in liver cells in vivo and in vitro.
IARC Sci. Publ. (124) , 189-93, (1993) The binding of 1-hydroxymethylpyrene (HMP) and its active metabolites, 1-hydroxymethylpyrene sulfate (SMP) and 1-chloromethylpyrene (CMP), to DNA was studied. In the liver of rats, maximum adduct levels were observed 1.5 h after i.p. injection of HMP, followe... |
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Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells.
Environ. Health Perspect. 88 , 43-8, (1990) Methylated polycyclic aromatic hydrocarbons are common in the human environment. Many of them are stronger carcinogens than their purely aromatic congeners. They may be metabolized to benzylic alcohols. We report here on biochemical and toxicological characte... |
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Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations.
Chem. Biol. Interact. 92(1-3) , 119-28, (1994) Various benzylic alcohols are metabolically activated to electrophilic, potentially mutagenic and carcinogenic sulphuric acid esters. The involved sulphotransferases are not expressed in the cell lines in culture which are commonly used for mutagenicity testi... |