Ac-Asp-Glu-Val-Asp-AFC

Ac-Asp-Glu-Val-Asp-AFC Structure
Ac-Asp-Glu-Val-Asp-AFC structure
Common Name Ac-Asp-Glu-Val-Asp-AFC
CAS Number 201608-14-2 Molecular Weight 729.612
Density 1.5±0.1 g/cm3 Boiling Point 1152.7±65.0 °C at 760 mmHg
Molecular Formula C30H34F3N5O13 Melting Point N/A
MSDS Chinese USA Flash Point 650.9±34.3 °C

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

Biochem. Pharmacol. 95 , 16-27, (2015)

Nitrobenzoxadiazoles exert antitumor effects against vemurafenib-resistant melanoma cells by sustained activation of different MAPK pathways.

Inhibition of ovarian cancer cell growth by a novel TAK1 inhibitor LYTAK1.

Cancer Chemother. Pharmacol. 76 , 641-50, (2015)

Transforming growth factor-β-activating kinase 1 (TAK1) has been implicated in promoting ovarian cancer progression. Here, we evaluated the anti-ovarian cancer effect of LYTAK1, a novel and specific TAK1 inhibitor.Established or primary human ovarian cancer c...

AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.

Am. J. Physiol. Endocrinol. Metab. 309 , E275-82, (2015)

Adiponectin (APN) is a cardioprotective molecule. Its reduction in diabetes exacerbates myocardial ischemia/reperfusion (MI/R) injury. Although APN administration in animals attenuates MI/R injury, multiple factors limit its clinical application. The current ...

Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening.

Molecules 19(11) , 19209-19, (2014)

We describe a ligand-based approach towards compounds with more specific targeting for Burkitt's lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically d...

Tat/HA2 Peptides Conjugated AuNR@pNIPAAm as a Photosensitizer Carrier for Near Infrared Triggered Photodynamic Therapy.

Mol. Pharm. 12 , 2444-58, (2015)

To achieve an efficiency of intracellular photosensitizers (PSs) delivery and efficacy of photodynamic therapy, we have developed a novel class of PS formulation for encapsulating sulfonated aluminum phthalocyanine (AlPcS4) by taking advantage of the membrane...

N-acetylcysteine relieves oxidative stress and protects hippocampus of rat from radiation-induced apoptosis by inhibiting caspase-3.

Biomed. Pharmacother. 70 , 1-6, (2015)

It has been recognized that radiation-induced effects remain a significant risk. An accumulation of reactive oxygen species (ROS) is considered to be one factor that contributes to neurodegenerative changes. The aim of our study was to investigate the potenti...

Azorella compacta methanolic extract induces apoptosis via activation of mitogen-activated protein kinase.

Mol. Med. Report. 12 , 6821-8, (2015)

Azorella compacta Phil. (AC) is an alpine medicinal plant used traditionally for antibacterial treatment. Recent studies have revealed that this plant also has anti‑diabetic effects, but that it is toxic. The present study investigated the underlying mechanis...

Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells.

Exp. Cell Res. 336 , 308-17, (2015)

This study aims to explore the detail molecular mechanism by which artesunate (ARS), an artemisinin derivative, induces apoptosis in HepG2 cells. ARS induced a loss of mitochondrial transmemberane potential (ΔΨm), phosphatidylserine (PS) externalization, as w...

Gene expression profiling identifies the novel role of immunoproteasome in doxorubicin-induced cardiotoxicity.

Toxicology 333 , 76-88, (2015)

The most well-known cause of chemotherapy-induced cardiotoxicity is doxorubicin (DOX). The ubiquitin-proteasome system (UPS) is the main cellular machinery for protein degradation in eukaryotic cells. However, the expression pattern of the UPS in DOX-induced ...

Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate.

Biosci. Rep. , (2014)

Caspase-2 is an evolutionarily conserved but enigmatic protease whose biological role remains poorly understood. To date, research into the functions of caspase-2 has been hampered by an absence of reagents that can distinguish its activity from that of the d...