(R,S)-MCPG
(R,S)-MCPG structure
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Common Name | (R,S)-MCPG | ||
|---|---|---|---|---|
| CAS Number | 146669-29-6 | Molecular Weight | 209.19900 | |
| Density | 1.39g/cm3 | Boiling Point | 230 °C17 mm Hg(lit.) | |
| Molecular Formula | C10H11NO4 | Melting Point | 95-98 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 221-223°C/10mm | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Dopamine triggers heterosynaptic plasticity.
J. Neurosci. 33(16) , 6759-65, (2013) As a classic neuromodulator, dopamine has long been thought to modulate, rather than trigger, synaptic plasticity. In contrast, our present results demonstrate that within the parallel projections of dopaminergic and GABAergic terminals from the ventral tegme... |
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The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling.
J. Neurosci. 33(38) , 15184-94, (2013) Our laboratory has demonstrated that 17β-estradiol (E2) enhances hippocampal memory consolidation via rapid activation of multiple intracellular signaling cascades, including the ERK/MAPK cascade (Fernandez et al., 2008; Fan et al., 2010). However, the recept... |
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The functional role of ascending nociceptive control in defensive behavior
Brain Res. 1464 , 24-9, (2012) Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, we used the dorsal immobility response ... |
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NMDA receptor, PKC and ERK prevent fos expression induced by the activation of group I metabotropic glutamate receptors in the spinal trigeminal subnucleus oralis.
Mol. Cells 30(5) , 461-6, (2010) Fos, a protein product of immediate early gene c-fos, has been used as a marker for activation of nociceptive neurons in central nervous system including spinal trigeminal nucleus (Vsp). By noxious stimulation applied to orofacial area, the expression of Fos ... |
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Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.
J. Neurophysiol. 106(5) , 2642-52, (2011) Pain-related hyperactivity in the amygdala leads to deactivation of the medial prefrontal cortex (mPFC) and decision-making deficits. The mechanisms of pain-related inhibition of the mPFC are not yet known. Here, we used extracellular single-unit recordings o... |
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Differential involvement of mGluR1 and mGluR5 in memory reconsolidation and retrieval in a passive avoidance task in 1-day old chicks.
Neurobiol. Learn. Mem. 97(1) , 165-72, (2012) Group I metabotropic glutamate receptors (mGluRs) are involved in memory formation. The Ca2+ signal derived from stimulation of IP3 receptors (IP3Rs) via mGluRs, initiates protein synthesis that is required for memory consolidation and reconsolidation. Howeve... |
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Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons.
J. Neurosci. 31(15) , 5777-81, (2011) Several subtypes of interneurons in the feedback circuit in stratum oriens of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) at glutamatergic synapses made by local pyramidal neurons. LTP has been reported with both "Hebbian" a... |
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Parasagittally aligned, mGluR1-dependent patches are evoked at long latencies by parallel fiber stimulation in the mouse cerebellar cortex in vivo.
J. Neurophysiol. 105(4) , 1732-46, (2011) The parallel fibers (PFs) in the cerebellar cortex extend several millimeters along a folium in the mediolateral direction. The PFs are orthogonal to and cross several parasagittal zones defined by the olivocerebellar and corticonuclear pathways and the expre... |
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Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo.
Neuroscience 162(3) , 713-22, (2009) Long-term potentiation (LTP) of parallel fiber-Purkinje cell (PF-PC) synapses in the cerebellum has been suggested to underlie aspects of motor learning. Previous in vitro studies have primarily used low frequency PF stimulation conditioning paradigms to gene... |