Necrostatin-1
Necrostatin-1 structure
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Common Name | Necrostatin-1 | ||
|---|---|---|---|---|
| CAS Number | 4311-88-0 | Molecular Weight | 259.327 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 441.9±37.0 °C at 760 mmHg | |
| Molecular Formula | C13H13N3OS | Melting Point | 151ºC | |
| MSDS | Chinese USA | Flash Point | 221.1±26.5 °C | |
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Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection.
Int. J. Med. Microbiol. 304(5-6) , 530-41, (2014) Shigella infection in epithelial cells induces cell death which is accompanied by mitochondrial dysfunction. In this study the role of the mitochondrial fission protein, Drp1 during Shigella infection in HeLa cells was examined. Significant lactate dehydrogen... |
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Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells.
Autophagy 10(7) , 1285-300, (2014) Transition metal copper (Cu) can exist in oxidized or reduced states in cells, leading to cytotoxicity in cancer cells through oxidative stress. Recently, copper complexes are emerging as a new class of anticancer compounds. Here, we report that a novel antic... |
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Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy.
Autophagy 11(2) , 214-24, (2015) Both apoptosis ("self-killing") and autophagy ("self-eating") are evolutionarily conserved processes, and their crosstalk influences anticancer drug sensitivity and cell death. However, the underlying mechanism remains unclear. Here, we demonstrated that HMGB... |
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Nat. Chem. Biol. 1 , 112-119, (2005) The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, w... |
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Proton nuclear magnetic resonance studies on methylthiohydantoins, thiohydantoins, and hydantoins of amino acids.
Can. J. Biochem. 55 , 521-527, (1977) Proton magnetic resonance spectra of methylthiohydantoin (3-methyl-2-thiohydantoin), thiohydantoin (2-thiohydantoin), and hydantoin derivatives of amino acids were studied in dimethyl sulfoxide-d6. Their parent amino acids could be identified by the spectra. ... |
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Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Xia M, Meng G, Jiang A, et al.
Oncotarget 5(11) , 3907-18, (2014)
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