8-Br-cGMP(8-Bromo-cGMP)
8-Br-cGMP(8-Bromo-cGMP) structure
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Common Name | 8-Br-cGMP(8-Bromo-cGMP) | ||
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| CAS Number | 51116-01-9 | Molecular Weight | 446.083 | |
| Density | 2.96 g/cm3 | Boiling Point | 794.3ºC at 760 mmHg | |
| Molecular Formula | C10H10BrN5NaO7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 434.2ºC | |
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Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.
PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-contracted with KCl or carbachol (CCh), and the phosphorylat... |
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Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.
Br. J. Pharmacol. 171(24) , 5858-69, (2014) Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian rhythms and modifies phase changes in SCN-operated rhyth... |
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Platelet-derived HMGB1 is a critical mediator of thrombosis.
J. Clin. Invest. 125 , 4638-54, (2015) Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular pattern molecule high-mobility group box 1 (HMGB1) is upregulat... |
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Effects of atrial natriuretic peptide on rat ventricular fibroblasts during differentiation into myofibroblasts.
Physiol. Res. 64 , 495-503, (2015) Atrial natriuretic peptide antifibrotic properties are mainly described in cardiac myocytes or in induced cardiac myofibroblasts (Angiotensin II or TGF-beta induced differentiation). In the present work, we investigate the effects of ANP/NPRA/cGMP system in m... |
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Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase.
Pflugers Arch. 466(10) , 1999-2008, (2014) Soluble guanylyl cyclase (sGC), phosphodiesterase type 5 (PDE5), and guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) are all dimeric. The present study was to determine the role of their dimeric status in nitric oxide-induced vasodi... |
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Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.
Plant Mol. Biol. 81(1-2) , 27-40, (2013) Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone layers. The inducible expressions of α-Amy2/54 and α-amylas... |
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Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation.
Cardiovasc. Res. 104(1) , 138-46, (2014) Vascular endothelial cells synthesize and release vasodilators such as nitric oxide (NO) and epoxyeicosatrienoic acids (EETs). NO is known to inhibit EET-induced smooth muscle hyperpolarization and relaxation. This study investigates the underlying mechanism ... |
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Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412.
PLoS ONE 9(4) , e95191, (2014) Neuronal Nitric Oxide Synthase (nNOS) is the biosynthetic enzyme responsible for nitric oxide (·NO) production in muscles and in the nervous system. This constitutive enzyme, unlike its endothelial and inducible counterparts, presents an N-terminal PDZ domain... |
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Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome.
Free Radic. Res. 48(11) , 1371-85, (2014) In this study, we show that exposure of human lung cancer A549 cells to cisplatin (cis-diamminedichloroplatinum, CDDP) promotes production of nitric oxide (NO) through generation of reactive oxygen species (ROS) and resulting upregulation of inducible NO synt... |
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CD147 up-regulates calcium-induced chemotaxis, adhesion ability and invasiveness of human neutrophils via a TRPM-7-mediated mechanism.
Rheumatology (Oxford.) 53(12) , 2288-96, (2014) We aimed to investigate whether CD147 can up-regulate the chemotactic, adhesive and invasive properties of human neutrophils and to determine the mechanism underlying this process.Human promyelocytic leukaemia cells (HL-60) cells and peripheral blood or synov... |