2-[(4-ETHOXYPHENYL)METHYL]-N,N-DIETHYL-5-ISOTHIOCYANO-1H-BENZIMIDAZOLE-1-ETHANAMINE

2-[(4-ETHOXYPHENYL)METHYL]-N,N-DIETHYL-5-ISOTHIOCYANO-1H-BENZIMIDAZOLE-1-ETHANAMINE Structure
2-[(4-ETHOXYPHENYL)METHYL]-N,N-DIETHYL-5-ISOTHIOCYANO-1H-BENZIMIDAZOLE-1-ETHANAMINE structure
Common Name 2-[(4-ETHOXYPHENYL)METHYL]-N,N-DIETHYL-5-ISOTHIOCYANO-1H-BENZIMIDAZOLE-1-ETHANAMINE
CAS Number 85951-65-1 Molecular Weight 408.56000
Density 1.13g/cm3 Boiling Point 595ºC at 760 mmHg
Molecular Formula C23H28N4OS Melting Point 64-66ºC
MSDS USA Flash Point 313.6ºC

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Nat. Genet. 47 , 1030-7, (2015)

Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we identified to our knowledge the first unifying genetic network common to the two subgroups of KMT2A (MLL)-rearranged leukemia, namely having MLL fusions or partial tandem d...

The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.

Stem Cells 33 , 2268-79, (2015)

Hematopoietic stem/progenitor cells (HSPCs) are regulated through numerous molecular mechanisms that have not been interconnected. The transcription factor stem cell leukemia/T-cell acute leukemia 1 (TAL1) controls human HSPC but its mechanism of action is no...

Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells.

J. Virol. 89 , 6536-50, (2015)

Endothelial cells (ECs) are a critical target of viruses, and infection of the endothelium represents a defining point in viral pathogenesis. Human cytomegalovirus (HCMV), the prototypical betaherpesvirus, encodes proteins specialized for entry into ECs and d...

Methylisothiazolinone in selected consumer products in Belgium: Adding fuel to the fire?

Contact Dermatitis 73 , 142-9, (2015)

Methylisothiazolinone (MI) contact allergy is severely affecting consumers with allergic contact dermatitis, owing to its presence in cosmetics, household detergents, and water-based paints, in particular. Data on the true isothiazolinone concentrations in th...

A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs.

PLoS ONE 6(3) , e17829, (2011)

Human ESC and iPSC are an attractive source of cells of high quantity and purity to be used to elucidate early human development processes, for drug discovery, and in clinical cell therapy applications. To efficiently differentiate pluripotent cells into a pu...

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia.

Oncotarget 6 , 38061-78, (2015)

We investigated cell cycle regulation in acute myeloid leukemia cells expressing the FLT3-ITD mutated tyrosine kinase receptor, an underexplored field in this disease. Upon FLT3 inhibition, CDC25A mRNA and protein were rapidly down-regulated, while levels of ...

Cross-linking of [125I]beta-endorphin to mu-opioid receptors during development.

Brain Res. Dev. Brain Res. 45(2) , 283-9, (1989)

Radioiodinated human beta-endorphin was cross-linked to opioid receptors from rat brain membranes using the bifunctional reagents bis-[2-(succinimidooxycarbonyloxy)ethyl] sulfone (BSCOES) and disuccinimidyl suberate (DSS). Major radiolabeled bands migrated wi...

Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells.

PLoS ONE 10 , e0126968, (2015)

The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved in cellular adhesion, innate immunity ...

Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors.

J. Exp. Med. 196 , 1141-9, (2002)

Human hematopoietic tissue contains rare stem cells with multilineage reconstituting ability demonstrable in receptive xenogeneic hosts. We now show that within 3 wk nonobese diabetic severe combined immunodeficiency (NOD/SCID) mice transplanted with human fe...

Multidisciplinary Proactive Psychiatric Consultation Service: Impact on Length of Stay for Medical Inpatients.

Psychother. Psychosom. 84 , 208-16, (2015)

Mental illness correlates with an increased length of stay (LOS) for patients hospitalized for medical conditions. While psychiatric consultations help manage mental illness among those hospitalized for medical conditions, consultations initiated by nonpsychi...