Luzindole
Luzindole structure
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Common Name | Luzindole | ||
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| CAS Number | 117946-91-5 | Molecular Weight | 292.375 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 559.6±38.0 °C at 760 mmHg | |
| Molecular Formula | C19H20N2O | Melting Point | 44-46°C | |
| MSDS | USA | Flash Point | 292.2±26.8 °C | |
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Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors.
Reprod. Biomed. Online 31 , 638-46, (2015) The aim of the present study was to elucidate whether the GATA-4/SF-1 signalling pathway is involved in the inhibitory effects of melatonin on testosterone production in both the TM3 Leydig cell line and in C57BL/6J mice. In-vitro experiments demonstrated tha... |
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Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis.
Brain Struct. Funct. 220(2) , 827-40, (2015) Although melatonin is mainly produced by the pineal gland, an increasing number of extra-pineal sites of melatonin synthesis have been described. We previously demonstrated the existence of bidirectional communication between the pineal gland and the immune s... |
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The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies.
J. Physiol. Pharmacol. 65(6) , 777-84, (2015) Melatonin exerts its biological role acting via G protein-coupled membrane receptors - MT1 and MT2, as well as through cytoplasmic and/or nuclear receptors. Melatonin has previously been shown to change vasopressin (AVP) and adrenocorticotropic hormone (ACTH)... |
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Role of melatonin and luzindole in rat mammary cancer.
J. Invest. Surg. 25(6) , 345-53, (2012) Recent studies have analyzed the efficacy of various agents in experimental chemoprevention trials. In our study, the effects of melatonin (Mel) and its antagonist Luzindole (Luz) on Heme oxygenase-1 (HO-1) in a NMU (N-methyl-N-nitrosourea)-induced rat mammar... |
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Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells.
Br. J. Cancer 101 , 1613-9, (2009) Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate th... |
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Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis.
Crit. Care Med. 42(1) , e22-31, (2014) Melatonin has been demonstrated to improve survival after experimental sepsis via antioxidant effects. Yet, recent evidence suggests that this protective capacity may also rely on melatonin receptor activation. Therefore, the present study was designed to inv... |
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Melatonin inhibits alcohol-induced increases in duodenal mucosal permeability in rats in vivo.
Am. J. Physiol. Gastrointest. Liver Physiol. 305(1) , G95-G105, (2013) Increased intestinal permeability is often associated with epithelial inflammation, leaky gut, or other pathological conditions in the gastrointestinal tract. We recently found that melatonin decreases basal duodenal mucosal permeability, suggesting a mucosal... |
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Melatonin down-regulates volume-sensitive chloride channels in fibroblasts.
Pflugers Arch. 464(3) , 273-85, (2012) Melatonin has been reported to present with vasorelaxant and anti-fibrotic properties. We hypothesized that melatonin may down-regulate volume-regulated anion channels (VRAC) in fibroblasts to limit their migration and proliferation. While acute exposure of L... |
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Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in mice.
Chem. Biol. Interact. 205(2) , 148-56, (2013) Our great interest in this work was study the synergism between l-tryptophan and dipyrone or paracetamol as well as the interaction of kynurenic acid (l-tryptophan metabolite) and these analgesics agents utilizing a robust methodology.We performed the writhin... |
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Melatonin elicits protein kinase C-mediated calcium response in immortalized GT1-7 GnRH neurons.
Brain Res. 1435 , 24-8, (2012) Melatonin is suggested to have effects on hypothalamic-pituitary-gonadal (HPG) axis. The pulsatile pattern of GnRH release, which results in the intermittent release of gonadotropic hormones from the pituitary, has a critical importance for reproductive funct... |