HCTU

HCTU Structure
HCTU structure
Common Name HCTU
CAS Number 330645-87-9 Molecular Weight 413.69
Density N/A Boiling Point N/A
Molecular Formula C11H15ClF6N5OP Melting Point 185-190 °C
MSDS USA Flash Point N/A

Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors.

Bioconjug. Chem. 22 , 777-784, (2011)

Highly tumor selective near-infrared (NIR) pH-activatable probe was developed by conjugating pH-sensitive cyanine dye to a cyclic arginine-glycine-aspartic acid (cRGD) peptide targeting α(v)β(3) integrin (ABIR), a protein that is highly overexpressed in endot...

Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates.

Bioorg. Med. Chem. 18 , 2887-2893, (2010)

We designed and synthesized human telomere alkylating N-methylpyrrole-N-methylimidazole (PI) polyamide conjugates (1-6). The C-type conjugates 1-3 possessed a chlorambucil moiety at the C terminus, whereas the N-type conjugates 4-6 had one of these moieties a...

Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors.

Org. Biomol. Chem. 8 , 1885-1893, (2010)

The synthesis and biological evaluation of ten Michael acceptors containing potential proteasome inhibitors are described. Cellular targets of azide containing inhibitors and were assessed in HEK293T and RAW264.7 cells by a two step labeling strategy, followe...

Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots.

J. Am. Chem. Soc. 132 , 10027-10033, (2010)

Water solubilized nanoparticles such as CdSe-ZnS core-shell nanocrystals (quantum dots, QDs) have great potential in bioimaging and sensing applications due to their excellent photophysical properties. However, the efficient modification of QDs with complex b...

Tandem oligonucleotide synthesis on solid-phase supports for the production of multiple oligonucleotides.

J. Org. Chem. 67 , 856, (2002)

More than one oligonucleotide can be synthesized at a time by linking multiple oligonucleotides end-to-end in a tandem manner on the surface of a solid-phase support. The 5'-terminal hydroxyl position of one oligonucleotide serves as the starting point for th...

Fast conventional synthesis of human beta-amyloid (1-42) on the Symphony and Prelude.

Adv. Exp. Med. Biol. 611 , 173-174, (2009)