FLUTRIMAZOLE
FLUTRIMAZOLE structure
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Common Name | FLUTRIMAZOLE | ||
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| CAS Number | 119006-77-8 | Molecular Weight | 346.373 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 457.1±40.0 °C at 760 mmHg | |
| Molecular Formula | C22H16F2N2 | Melting Point | 161-166ºC | |
| MSDS | N/A | Flash Point | 230.3±27.3 °C | |
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Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream.
Mycoses 43(9-10) , 355-65, (2000) A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal candidosis. Vaginitis was demonstrated by both positive fi... |
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Efficacy of flutrimazole 1% powder in the treatment of tinea pedis.
Mycoses 46(3-4) , 126-31, (2003) The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comparative study was conducted. Two hundred and twenty-two pat... |
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Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial.
Mycoses 53(6) , 522-9, (2010) Fluconazole, which is a drug of the azole family, is safely used in systemic treatment of oral and intravenous injection, but it is difficult to use fluconazole as a topical application because of its large molecular weight and strong hydrophilic property. Th... |
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Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent.
Inflamm. Res. 45(1) , 20-5, (1996) The topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal, have been evaluated. Flutrimazole inhibited mouse ear oedema induced by arachidonic acid, tetradecanoylphorbol-acetate and dithranol, with IC50 values of 3.32, 0.55 and 2.42... |
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Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women.
Arzneimittelforschung 48(5) , 512-7, (1998) In order to improve the effectiveness of treatment of vaginal yeast infections, flutrimazole, (CAS 119006-77-8), a broad spectrum local imidazolic fungicide, has been formulated in an advanced delivery system (Site Release, here in after briefly referred to a... |
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A double-blind, randomized comparative trial: flutrimazole 1% solution versus bifonazole 1% solution once daily in dermatomycoses.
Mycoses 38(9-10) , 395-403, (1995) In a double-blind, randomized study the efficacy and tolerance of flutrimazole 1% solution were compared with bifonazole 1% solution, applied once daily for 4 weeks, in 40 patients with culturally proven dermatophytosis or cutaneous candidosis. Forty patients... |
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[Facial dermatophytide reaction].
An. Pediatr. (Barc.) 68(4) , 411-2, (2008)
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In vitro and in vivo studies with flutrimazole, a new imidazole derivative with antifungal activity.
Arzneimittelforschung 42(6) , 836-40, (1992) 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) is a new topical imidazole antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts, sapr... |
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Percutaneous absorption and skin distribution of [14C]flutrimazole in mini-pigs.
Arzneimittelforschung 42(6) , 847-53, (1992) The percutaneous absorption and skin distribution of a skin cream containing 1% 14C-labelled 1-[(fluorophenyl) (4-fluorophenyl) phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) was studied in minipigs. The same dose of flutrimazole was admi... |
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Synthesis and antifungal activity of a series of difluorotritylimidazoles.
Arzneimittelforschung 42(6) , 832-5, (1992)
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