3'-deoxythymidine-5'-o-triphosphate/2',3'-dideoxythymidine-5'-o-triphosphate sodium salt
3'-deoxythymidine-5'-o-triphosphate/2',3'-dideoxythymidine-5'-o-triphosphate sodium salt structure
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Common Name | 3'-deoxythymidine-5'-o-triphosphate/2',3'-dideoxythymidine-5'-o-triphosphate sodium salt | ||
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| CAS Number | 128524-26-5 | Molecular Weight | 488.15100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H16N2NaO13P3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Nicked-site substrates for a serine recombinase reveal enzyme-DNA communications and an essential tethering role of covalent enzyme-DNA linkages.
Nucleic Acids Res. 43 , 6134-43, (2015) To analyse the mechanism and kinetics of DNA strand cleavages catalysed by the serine recombinase Tn3 resolvase, we made modified recombination sites with a single-strand nick in one of the two DNA strands. Resolvase acting on these sites cleaves the intact s... |
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Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.
Nucleic Acids Res. 41 , 3257-73, (2013) In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked nucleic ac... |
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A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation.
Epigenetics Chromatin 3 , 12, (2010) DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding... |
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Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
Biochem. Biophys. Res. Commun. 88(4) , 1255-62, (1979)
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Inhibition of HIV-associated reverse transcriptase by sugar-modified derivatives of thymidine 5'-triphosphate in comparison to cellular DNA polymerases alpha and beta.
Biochem. Biophys. Res. Commun. 148(1) , 78-85, (1987) The sugar-modified dTTP analogues 2',3'-didehydro-2',3'-dideoxy-thymidine 5'-triphosphate (ddeTTP), 2',3'-dideoxythymidine 5'-triphosphate (ddTTP), 3'-fluorothymidine 5'-triphosphate (FdTTP), and 3'-azidothymidine 5'-triphosphate (N3dTTP) are demonstrated to ... |
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Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins.
Nucleic Acids Res. 39(21) , 9250-61, (2011) Bacillus subtilis pnpA gene product, polynucleotide phosphorylase (PNPase), is involved in double-strand break (DSB) repair via homologous recombination (HR) or non-homologous end-joining (NHEJ). RecN is among the first responders to localize at the DNA DSBs,... |
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Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase.
Nucleic Acids Res. 36 , 1990-2001, (2008) Our previous publication shows that Sulfolobus solfataricus Dpo4 utilizes an 'induced-fit' mechanism to select correct incoming nucleotides at 37 degrees C. Here, we provide a comprehensive report elucidating the kinetic mechanism of a DNA polymerase at a rea... |
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Mutation in ribosomal protein S5 leads to spectinomycin resistance in Neisseria gonorrhoeae.
Front. Microbiol. 4 , 186, (2013) Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of... |
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A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair.
Nucleic Acids Res. 38 , 1853-65, (2010) The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex ... |
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Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly.
Proc. Natl. Acad. Sci. U. S. A. 112 , E4707-16, (2015) Ribosome biogenesis requires multiple assembly factors. In Escherichia coli, deletion of RlmE, the methyltransferase responsible for the 2'-O-methyluridine modification at position 2552 (Um2552) in helix 92 of the 23S rRNA, results in slow growth and accumula... |