N-Acetylcytidine
N-Acetylcytidine structure
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Common Name | N-Acetylcytidine | ||
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| CAS Number | 3768-18-1 | Molecular Weight | 285.253 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H15N3O6 | Melting Point | 199ºC (dec.) | |
| MSDS | N/A | Flash Point | N/A | |
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Exometabolom analysis of breast cancer cell lines: Metabolic signature.
Sci. Rep. 5 , 13374, (2015) Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of different subtypes of breast cancer cell lines and the breast epith... |
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Least absolute shrinkage and selection operator and dimensionality reduction techniques in quantitative structure retention relationship modeling of retention in hydrophilic interaction liquid chromatography.
J. Chromatogr. A. 1403 , 54-62, (2015) The objective of this study was to model the retention of nucleosides and pterins in hydrophilic interaction liquid chromatography (HILIC) via QSRR-based approach. Two home-made (Amino-P-C18, Amino-P-C10) and one commercial (IAM.PC.DD2) HILIC stationary phase... |
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The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression.
Nucleic Acids Res. 41(11) , 5669-78, (2013) The conserved pre-mRNA retention and splicing (RES) complex, which in yeast consists of Bud13p, Snu17p and Pml1p, is thought to promote nuclear retention of unspliced pre-mRNAs and enhance splicing of a subset of transcripts. Here, we find that the absence of... |
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Use of biological fluids for the rapid diagnosis of potentially lethal inherited disorders of human purine and pyrimidine metabolism.
Biomed. Chromatogr. 1(3) , 109-18, (1986) Inherited purine and pyrimidine disorders may be associated with serious, sometimes life-threatening consequences. Early and accurate diagnosis is essential. Difficulties encountered when using existing high pressure liquid chromatographic (HPLC) methods led ... |
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A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress.
PLoS Genet. 6 , e1001247, (2010) Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly prec... |
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The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.
EMBO J. 27(16) , 2194-203, (2008) The wobble base of Escherichia coli elongator tRNA(Met) is modified to N(4)-acetylcytidine (ac(4)C), which is thought to ensure the precise recognition of the AUG codon by preventing misreading of near-cognate AUA codon. By employing genome-wide screen of unc... |
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The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA.
RNA 10(4) , 712-9, (2004) The biogenesis of transfer RNA is a process that requires many different factors. In this study, we describe a genetic screen aimed to identify gene products participating in this process. By screening for mutations lethal in combination with a sup61-T47:2C a... |
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Urinary nucleosides as biological markers for patients with colorectal cancer.
World J. Gastroenterol. 11(25) , 3871-6, (2005) Fourteen urinary nucleosides, primary degradation products of tRNA, were evaluated to know the potential as biological markers for patients with colorectal cancer.The concentrations of 14 kinds of urinary nucleosides from 52 patients with colorectal cancer, 1... |
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Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process.
Br. J. Rheumatol. 36(9) , 990-5, (1997) The levels of the five methylated nucleosides pseudouridine (psi-Urd), 1-methyladenosine (1-MeAdo), 4 acetylcytidine (4-AcCyd), 1 methylinosine (1-Melno) and 7 methylguanosine (7-MeGuo) resulting from RNA degradation were examined in the urine of rheumatoid a... |
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Conformational characteristics of 4-acetylcytidine found in tRNA.
Nucleic Acids Symp. Ser. (21) , 61-2, (1989) The conformational characteristics of a modified nucleoside 4-acetylcytidine (ac4C) was analyzed by proton nuclear magnetic resonance spectroscopy. This nucleoside was found to take the C3'-endo form predominantly. The enthalpy difference between the C2'-endo... |