Harmaline
Harmaline structure
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Common Name | Harmaline | ||
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| CAS Number | 304-21-2 | Molecular Weight | 214.263 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 426.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H14N2O | Melting Point | 232-234 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 211.7±28.7 °C | |
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High-throughput screening for new psychoactive substances (NPS) in whole blood by DLLME extraction and UHPLC-MS/MS analysis.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 57-68, (2015) The increasing number of new psychoactive substances (NPS) present in the illicit market render their identification in biological fluids/tissues of great concern for clinical and forensic toxicology. Analytical methods able to detect the huge number of subst... |
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Fast determination of harmala alkaloids in edible algae by capillary electrophoresis mass spectrometry.
Anal. Bioanal. Chem 407(13) , 3637-45, (2015) The use of algae as a foodstuff is rapidly expanding worldwide from the East Asian countries, where they are also used for medical care. Harmala alkaloids (HAlk) are a family of bioactive compounds found in the extracts of some plants, including wakame (Undar... |
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Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS.
J. Pharm. Biomed. Anal. 94 , 215-20, (2014) Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are legitimate therapeutic targets for Alzheimer's disease. The classical approach for screening potential AChE/BChE inhibitors was developed by Ellman. However, the background color of compounds or... |
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Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum.
J. Neurosci. 35(2) , 843-52, (2015) Simple and regular anatomical structure is a hallmark of the cerebellar cortex. Parasagittally arrayed alternate expression of aldolase C/zebrin II in Purkinje cells (PCs) has been extensively studied, but surprisingly little is known about its functional sig... |
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Interaction of β-carboline alkaloids with RNA.
DNA Cell. Biol. 29 , 753-761, (2010) β-Carboline alkaloids are present in medicinal plants such as Peganum harmala L., which have been used as folk medicine in anticancer therapy. Recently, they have drawn attention because of their antitumor activities. Despite considerable interest and investi... |
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Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops.
Molecules 18(3) , 2623-34, (2013) Alkaloids with allelopathic activity are not as well-known as other allelochemicals. Our study revealed that total alkaloids from seeds of the medicinal plant Peganum harmala L. possessed significant growth inhibitory effect on four treated plants, with dicot... |
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Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells.
BMB Rep. 43 , 824-829, (2010) Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. _-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Present... |
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Harmaline attenuates voltage--sensitive Ca(2+) currents in neurons of the inferior olive.
J. Pharm. Pharm. Sci. 15(5) , 657-68, (2012) Harmaline is one member of a class of tremorgenic harmala alkaloids that have been implicated in neuroprotective effects and neurodegenerative disorders. It has been reported to interact with several neurotransmitter receptors as well as ion exchangers and vo... |
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Harmaline-resistant mutant of Methanothermobacter thermautotrophicus with a lesion in Na(+)/H(+) antiport.
Gen. Physiol. Biophys. 30 Spec No , S54-60, (2011) A spontaneous mutant of Methanothermobacter thermautotrophicus resistant to the Na(+)/H(+) antiporter inhibitor harmaline was isolated. The Na(+)/H(+) exchange activity in the mutant cells was remarkably decreased in comparison with wild-type cells. Na(+)/H(+... |
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Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits.
Am. J. Physiol. Renal Physiol. 304(7) , F883-99, (2013) In the basolateral membrane of proximal-tubule cells, NBCe1-A (SLC4A4, variant A), operating with an apparent Na(+):HCO(3)(-) stoichiometry of 1:3, contributes to the reclamation of HCO(3)(-) from the glomerular filtrate, thereby preventing whole body acidosi... |