δ-Tocotrienol
δ-Tocotrienol structure
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Common Name | δ-Tocotrienol | ||
|---|---|---|---|---|
| CAS Number | 25612-59-3 | Molecular Weight | 396.605 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 517.3±39.0 °C at 760 mmHg | |
| Molecular Formula | C27H40O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 212.8±21.3 °C | |
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Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
Cell Prolif. 46(2) , 203-13, (2013) Tocotrienols and tocopherols are members of the vitamin E family, with similar structures; however, only tocotrienols have been reported to achieve potent anti-cancer effects. The study described here has evaluated anti-cancer activity of vitamin E to elucida... |
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δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.
Microsc. Microanal. 18(3) , 462-9, (2012) Tocotrienols are isomers of the vitamin E family, which have been reported to exert cytotoxic effects in various cancer cells. Although there have been some reports on the effects of tocotrienols in leukemic cells, ultrastructural evidence of tocotrienol-indu... |
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Direct inhibition of osteoclast formation and activity by the vitamin E isomer gamma-tocotrienol.
Int. J. Vitam. Nutr. Res. 81(6) , 358-67, (2011) Vitamin E homologues, specifically tocotrienols, have been shown to have favorable effects on bone. They possess properties that are indicative of anti-resorptive activity, suggesting the potential for vitamin E in preventing bone loss. To investigate the ant... |
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A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.
Biochem. J. 446(2) , 191-201, (2012) There is growing evidence showing that prostate cancer cells have perturbed cholesterol homoeostasis, accumulating cholesterol to promote cell growth. Consequently, cholesterol-lowering drugs such as statins are being evaluated in prostate cancer treatment. F... |
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Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
Exp. Biol. Med. (Maywood.) 236(5) , 604-13, (2011) The diterpene geranylgeraniol (all trans-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-ol) suppresses the growth of human liver, lung, ovary, pancreas, colon, stomach and blood tumors with undefined mechanisms. We evaluated the growth-suppressive activity... |
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Induction of DNA damage and caspase-independent programmed cell death by vitamin E.
Nutr. Cancer 64(1) , 136-52, (2012) Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and δ-tocotrienol (δ-TT)] and 4 synthetic de... |
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Mechanism of radioprotection by δ-tocotrienol: pharmacokinetics, pharmacodynamics and modulation of signalling pathways.
Br. J. Radiol. 85(1019) , e1093-103, (2012) The objective of this study was to investigate the correlation between in vivo δ-tocotrienol (DT3) pharmacokinetics, pharmacodynamics and radiation protection, and to evaluate the effect of DT3 pre-treatment on radiation-induced alterations in apoptotic and a... |
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Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin.
Lipids Health Dis. 10 , 239, (2011) Changes in immune function believed to contribute to a variety of age-related diseases have been associated with increased production of nitric oxide (NO). We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, δ-tocotrieno... |
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d-δ-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells.
Anticancer Res. 30(12) , 4937-44, (2010) The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of growth-related proteins. d-δ-tocotrienol, a post-transcriptional down-regul... |
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Delta-tocotrienol augments cisplatin-induced suppression of non-small cell lung cancer cells via inhibition of the Notch-1 pathway.
Anticancer Res. 32(7) , 2647-55, (2012) Non-small cell lung cancer (NSCLC), accounting for 80% of lung cancers, is the leading cause of all cancer deaths. Previously, we demonstrated that delta-tocotrienol inhibits NSCLC cell proliferation, invasion and induces apoptosis by down-regulation of the N... |