Herbimycin A
Herbimycin A structure
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Common Name | Herbimycin A | ||
|---|---|---|---|---|
| CAS Number | 70563-58-5 | Molecular Weight | 574.662 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 752.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C30H42N2O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 408.8±32.9 °C | |
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Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.
J. Nat. Prod. 76(9) , 1619-26, (2013) Bacterial strains belonging to the class actinomycetes were isolated from the soil near a thermal vent of the Ruth Mullins coal fire (Appalachian Mountains of eastern Kentucky). High-resolution electrospray ionization mass spectrometry and ultraviolet absorpt... |
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Herbimycin A inhibits cell growth with reversal of epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells.
Biochem. Biophys. Res. Commun. 455(3-4) , 363-70, (2014) We aimed to elucidate the effect of herbimycin A (HMA), a heat shock protein 90 inhibitor, on cell growth and epithelial-mesenchymal transition (EMT) in anaplastic thyroid carcinoma (ATC) cells. HMA inhibited cell growth and migration concomitantly with incre... |
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Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells.
Cell Biol. Int. 32(6) , 630-7, (2008) To investigate the role of tyrosine phosphorylation/dephosphorylation processes in plant cells the morphology of Arabidopsis thaliana primary roots and the organization of cortical microtubules (MTs) were studied after inhibition of protein tyrosine kinases (... |
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Effects of tyrosine kinase and phosphatase inhibitors on mitosis progression in synchronized tobacco BY-2 cells.
Tsitol. Genet. 46(5) , 3-11, (2012) To test whether reversible tubulin phosphorylation plays any role in the process of plant mitosis the effects of inhibitors of tyrosine kinases, herbimycin A, genistein and tyrphostin AG 18, and of an inhibitor of tyrosine phosphatases, sodium orthovanadate, ... |
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Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5.
Hematology 13(4) , 236-43, (2008) Fibronectin (FN) is thought to play an important role in various aspects of hematopoiesis through binding to very late antigen (VLA)-4 and VLA-5. Little is known, however, about the effects of FN on the proliferation of B cell progenitors. In this study, we i... |
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Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells.
Yonsei Med. J. 52(3) , 522-6, (2011) Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed in gastric cancer, and chronic expr... |
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Narrow-band UVB irradiation stimulates the migration and functional development of vitiligo-IgG antibodies-treated pigment cells.
J. Eur. Acad. Dermatol. Venereol. 26(4) , 456-64, (2012) The pathogenesis of vitiligo remains unclear. Most authorities favoured the autoimmune cause for the strong associations of vitiligo with multiple autoimmune diseases and the presence of autoantibodies in vitiligo patients. Narrow-band UVB (NBUVB) irradiation... |
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Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium.
Cell. Signal. 20(6) , 1159-68, (2008) Mutation or loss of MerTK as well as deficiency of alphavbeta5-integrins, gives rise to retinal-degeneration due to inefficient phagocytosis of photoreceptor outer-segment fragments by the retinal pigment epithelium (RPE). This study shows that Gas6 expressed... |
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Integrin-associated tyrosine kinase FAK affects Cbfa1 expression.
J. Orthop. Res. 29(9) , 1443-7, (2011) Following cell adhesion, focal adhesion kinase (FAK) autophosphorylates on tyrosine and regulates intracellular signaling cascades that regulate cell growth and differentiation. The hypothesis of this study was FAK mediates osteoblast differentiation dependen... |
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Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages.
J. Leukoc. Biol. 84(3) , 798-806, (2008) In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the entero... |