Dolastatin 15
Dolastatin 15 structure
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Common Name | Dolastatin 15 | ||
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| CAS Number | 123884-00-4 | Molecular Weight | 837.05600 | |
| Density | 1.2g/cm3 | Boiling Point | 943.2ºC at 760mmHg | |
| Molecular Formula | C45H68N6O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 524.2ºC | |
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End-binding proteins sensitize microtubules to the action of microtubule-targeting agents.
Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8900-5, (2013) Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improved microtubule-directed therapies. Although there is a larg... |
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The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.
Anticancer Drugs 6(3) , 392-7, (1995) The effects of dolastatin 10 (Dol10) and dolastatin 15 (Dol15) alone, and after treatment with bryostatin 1 (Bryo1), on human diffuse large cell lymphoma cell line (WSU-DLCL2) were studied. At a concentration of 1.0 ng/ml Dol10 and Dol15 showed significant gr... |
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Effects of dolastatins on human B-lymphocytic leukemia cell lines.
Leuk. Res. 17(4) , 333-9, (1993) Dolastatins are naturally occurring peptides isolated from marine animals and are known to be potent anti-neoplastic agents. Here, the three compounds dolastatin 10 (Dola 10), dolastatin 15 (Dola 15) and deo-dolastatin 10 (Deo-Dola 10) were added to cultures ... |
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Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates.
Cancer Chemother. Pharmacol. 70(3) , 439-49, (2012) Targeting tubulin binders to cancer cells using antibody-drug conjugates (ADCs) has great potential to become an effective cancer treatment with low normal tissue toxicity. The nature of the linker used to tether the tubulin binder to the antibody and the con... |
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Quantitation of dolastatin-10 using HPLC/electrospray ionization mass spectrometry: application in a phase I clinical trial.
Cancer Chemother. Pharmacol. 41(4) , 299-306, (1998) A highly sensitive and specific assay for the quantitation of the anticancer agent dolastatin-10 (DOL-10) in human plasma is described. The method was based on the use of electrospray ionization-high-performance liquid chromatography/mass spectrometry (ESP-LC... |
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A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells.
Int. J. Oncol. 30(6) , 1453-9, (2007) Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived from the marine mollusc Dolabella auricularia, which have recently been reported as an anti-cancer agent. Dolastatin 10 and 15 are... |
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A phase II study of the dolastatin 15 analogue LU 103793 in the treatment of advanced non-small-cell lung cancer.
Am. J. Clin. Oncol. 26(4) , 336-7, (2003) A phase II study of the dolastatin 15 analog LU 103793 was conducted by the North Central Cancer Treatment Group in patients with advanced non-small-cell lung cancer (SCLC). Previously untreated patients received this agent at a dosage of 2.5 mg/m2 as a 5-min... |
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Synthesis of Dolastatin 15 mimetic peptoids.
Bioorg. Med. Chem. Lett. 8(4) , 385-8, (1998) Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytost... |
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[Dolastatins].
Bull. Cancer 86(11) , 897-901, (1999)
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The dolastatins.
Fortschr. Chem. Org. Naturst. 70 , 1-79, (1997)
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