Scutellarin
Scutellarin structure
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Common Name | Scutellarin | ||
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| CAS Number | 27740-01-8 | Molecular Weight | 462.360 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 891.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H18O12 | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | 314.9±27.8 °C | |
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Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia.
J. Neuroinflammation 12 , 11, (2015) Activated microglial cells release an excess of inflammatory mediators after an ischemic stroke. We reported previously that scutellarin effectively suppressed the inflammatory response induced by activated microglia in rats subjected to middle cerebral arter... |
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[Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release].
Zhongguo Zhong Yao Za Zhi 38(6) , 817-20, (2013) To prepare the new traditional Chinese medicine preparation--pH-dependent brevisapin colon-specific tablets, and investigate its in vitro release, in order to discuss the feasibility of preparing colon-targeted traditional Chinese medicines.With scutellarin, ... |
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Effects of spray-drying and choice of solid carriers on concentrations of Labrasol® and Transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS).
Molecules 18(1) , 545-60, (2013) Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of solid SMEDDS. We inves... |
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Simultaneous determination of various bioactive redox components in Shuang–Huang–Lian preparations using a novel three-channel isocratic elution liquid chromatography with electrochemical detection system
J. Pharm. Biomed. Anal. 95 , 93-101, (2014) A novel three-channel isocratic elution high performance liquid chromatography with electrochemical detection (3LC-ECD) system was developed for the simultaneous determination of various bioactive redox components in Shuang-Huang-Lian (SHL) preparations. This... |
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Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism.
J. Ethnopharmacol. 164 , 301-8, (2015) Diosbulbin B (DB) is the main hepatotoxic compound distributed in Dioscorea bulbifera L., which is widely used for the treatment of cancer and thyroid disorders in Asia. Scutellarin (SC) is the main compound in medicinal herb Scutellaria barbata D. Don, which... |
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[Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS].
Zhongguo Zhong Yao Za Zhi 37(4) , 529-32, (2012) To establish a UPLC-MS/MS analysical method for simultaneous determination of concentrations of isoorientin, scutellarin and cynaroside in rat plasma and to study their pharmacokinetic characteristics after intravenous injection of 3 doses of Fufang Hongcao i... |
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[Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS].
Zhongguo Zhong Yao Za Zhi 36(22) , 3189-93, (2011) To establish an UPLC-MS/MS method for simultaneous determination protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of Compound Hongcao for injection, and investigate the distribution character of the thr... |
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Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats.
Phytother Res. 26(8) , 1226-30, (2012) Scutellarin is the most important flavone glycoside in the herbal drug Erigeron breviscapus (Vant.) Hand.-Mazz. It is used frequently in the clinic to treat ischemic vascular diseases in China. However, the direct relationship between scutellarin and cytochro... |
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Effect of light, methyl jasmonate and cyclodextrin on production of polyphenolic compounds in hairy root cultures of Scutellaria lateriflora
Phytochemistry 107 , 50-60, (2014) Graphical abstract [Display omitted] |
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Scutellarin from Scutellaria baicalensis suppresses adipogenesis by upregulating PPARα in 3T3-L1 cells.
J. Nat. Prod. 76(4) , 672-8, (2013) Adipocyte dysfunction is a major cause of obesity, which is associated strongly with many disorders including psychological and medical morbidities, metabolic abnormalities, and cardiovascular diseases as well as a series of cancers. This study investigated t... |