L-Methionine-DL-sulfoximine
L-Methionine-DL-sulfoximine structure
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Common Name | L-Methionine-DL-sulfoximine | ||
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| CAS Number | 15985-39-4 | Molecular Weight | 180.225 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 352.2±52.0 °C at 760 mmHg | |
| Molecular Formula | C5H12N2O3S | Melting Point | >210ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 166.8±30.7 °C | |
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Notch ligand delta-like1: X-ray crystal structure and binding affinity.
Biochem. J. 468 , 159-66, (2015) The Notch pathway is a fundamental signalling system in most multicellular animals. We have determined the X-ray crystal structure of the extracellular domain of the Notch ligand delta-like ligand-1 (Dll-1). The structure incorporates the N-terminal C2 domain... |
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Polyproline promotes tetramerization of recombinant human butyrylcholinesterase.
Biochem. J. 462(2) , 329-35, (2014) Human BChE (butyrylcholinesterase) protects against the toxicity of organophosphorus nerve agents and pesticides. BChE purified from human plasma is limited and pathogen carry-over is a concern. Unlike the native BChE tetrameric complex with a residence time ... |
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A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen.
PLoS ONE 10 , e0133595, (2015) In the HIV vaccine field, there is a need to produce highly immunogenic forms of the Env protein with the capacity to trigger broad B and T-cell responses. Here, we report the generation and characterization of a chimeric HIV-1 gp120 protein (termed gp120-14K... |
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Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody.
PLoS ONE 10(2) , e0118096, (2015) Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we... |
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Ephrin/Ephrin receptor expression in ammonia-treated rat astrocytes and in human cerebral cortex in hepatic encephalopathy.
Neurochem. Res. 40(2) , 274-83, (2015) Hepatic encephalopathy (HE) represents a neuropsychiatric syndrome, which evolves as a consequence of a low grade cerebral edema and a concomitant oxidative/nitrosative stress response. Ephrin receptors (EphR) and their ligands (ephrins) regulate astrocytic g... |
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Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.
PLoS Genet. 7(8) , e1002229, (2011) Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements. While many cancer cells depend on exogenous ... |
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HIV-1 gp41 core with exposed membrane-proximal external region inducing broad HIV-1 neutralizing antibodies.
PLoS ONE 6(3) , e18233, (2011) The membrane-proximal external region (MPER) of the HIV-1 gp41 consists of epitopes for the broadly cross-neutralizing monoclonal antibodies 2F5 and 4E10. However, antigens containing the linear sequence of these epitopes are unable to elicit potent and broad... |
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Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.
Biochemistry 48(4) , 779-85, (2009) The initial events of HIV-1 cell infection involve the sequential binding of the viral envelope glycoprotein gp120 to the cellular CD4 receptor and the coreceptor, usually CCR5 or CXCR4. Binding to the coreceptor triggers the chain of events that culminates w... |
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Glutamine deprivation initiates reversible assembly of mammalian rods and rings. Calise SJ, Carcamo WC, Krueger C, et al.
Cell. Mol. Life Sci. 71(15) , 2963-73, (2014)
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Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells.
Biotechnol. Bioeng. 109 , 1007-1015, (2012) Although Chinese hamster ovary (CHO) cells, with their unique characteristics, have become a major workhorse for the manufacture of therapeutic recombinant proteins, one of the major challenges in CHO cell line generation (CLG) is how to efficiently identify ... |