4-Amino-6-chlorobenzene-1,3-disulfonamide
4-Amino-6-chlorobenzene-1,3-disulfonamide structure
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Common Name | 4-Amino-6-chlorobenzene-1,3-disulfonamide | ||
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| CAS Number | 121-30-2 | Molecular Weight | 285.728 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 614.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C6H8ClN3O4S2 | Melting Point | 257-261 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 325.4±34.3 °C | |
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Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
Bioorg. Med. Chem. Lett. 16 , 2182-8, (2006) A library of sulfonamides/sulfamates has been investigated for the inhibition of the carboxyterminal truncated form of the alpha-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the gastric pathogen Helicobacter pylori (hpCA). This enzyme, incorporating 202 ... |
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Mass spectrometric behavior of thiazide-based diuretics after electrospray ionization and collision-induced dissociation.
Anal. Chem. 74(15) , 3802-8, (2002) The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and comm... |
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Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis
J. Chromatogr. A. 1216(12) , 2466-73, (2009) In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide diuretics include compounds which are very unstable and hydr... |
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Validated micellar electrokinetic capillary chromatography method for quality control of the drug substances hydrochlorothiazide and chlorothiazide.
J. Chromatogr. B, Biomed. Appl. 657(2) , 383-94, (1994) A stability-indicating, quality control analysis method was developed and validated for the diuretic drug substances hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ). Micellar electrokinetic capillary chromatography employing the anionic detergent sodium d... |
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Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.
Chem. Pharm. Bull. 35(8) , 3516-8, (1987)
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Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythrocytes.
Chem. Pharm. Bull. 38(10) , 2882-3, (1990) 2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatcha... |