Nadolol
Nadolol structure
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Common Name | Nadolol | ||
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| CAS Number | 42200-33-9 | Molecular Weight | 309.40100 | |
| Density | 1.189g/cm3 | Boiling Point | 526.4ºC at 760mmHg | |
| Molecular Formula | C17H27NO4 | Melting Point | 125-130ºC | |
| MSDS | USA | Flash Point | 272.2ºC | |
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Direct doping analysis of beta-blocker drugs from urinary samples by on-line molecularly imprinted solid-phase extraction coupled to liquid chromatography/mass spectrometry.
Analyst 140(8) , 2696-703, (2015) The use of beta-blockers to enhance performance in some sports is forbidden. Based on this regulation, there is a demand for dynamic analytical procedures for analyzing these compounds quickly and without manual sample preparation. Therefore, the use of a mol... |
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Versatile ene-thiol photoclick reaction for preparation of multimodal monolithic silica capillary columns.
J. Chromatogr. A. 1365 , 140-7, (2014) This paper presents a photografting process of monolithic silica capillary columns based on the ene-thiol click chemistry. This study is performed on a generic vinyl-functionalized silica monolith (Hmin 61m). The photoclick reaction is investigated using diff... |
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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Drug Metab. Dispos. 42(10) , 1656-62, (2014) The clinical development of fedratinib, a Janus kinase (JAK2) inhibitor, was terminated after reports of Wernicke's encephalopathy in myelofibrosis patients. Since Wernicke's encephalopathy is induced by thiamine deficiency, investigations were conducted to p... |
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Three column intermittent simulated moving bed chromatography: 3. Cascade operation for center-cut separations.
J. Chromatogr. A. 1378 , 37-49, (2015) A general design methodology for chromatographic three fraction separation by application of the three column intermittent simulated moving bed (3C-ISMB) cascade is proposed and experimentally validated by studying the purification of an intermediately retain... |
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Gaining insight in the behaviour of imidazolium-based ionic liquids as additives in reversed-phase liquid chromatography for the analysis of basic compounds.
J. Chromatogr. A. 1380 , 96-103, (2015) In reversed-phase liquid chromatography in the absence of additives, cationic basic compounds give rise to broad and asymmetrical peaks as a result of ionic interactions with residual free silanols on silica-based stationary phases. Ionic liquids (ILs), added... |
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Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.
Proc. Natl. Acad. Sci. U. S. A. 112(6) , E546-55, (2015) There are increased neutrophils in the lungs of patients with chronic obstructive pulmonary disease (COPD), but it is unclear if this is due to increased inflammatory signal or related to the inherent behavior of the neutrophils. This is critical, because ina... |
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Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans.
Mol. Cell. Biol. 29 , 3881-93, (2009) In Caenorhabditis elegans, the central cell-killing process is essentially controlled by the interplay of four apoptotic factors: EGL-1/BH3-only protein, CED-9/Bcl2, CED-4/Apaf1, and CED-3/caspase. In cells destined to die, EGL-1 binds to CED-9 and results in... |
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Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.
Clin. Pharmacol. Ther. 95(4) , 432-8, (2014) This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (7... |
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Randomized, controlled trial of carvedilol versus nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding.
J. Gastroenterol. Hepatol. 27(11) , 1681-7, (2012) Carvedilol has been shown to be more effective than propranolol in decreasing portal pressure. Sufficient data from controlled trials remains limited. This trial compared the relative safety and efficacy between carvedilol and nadolol plus isosorbide mononitr... |
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Adding banding ligation is effective as rescue therapy to prevent variceal rebleeding in haemodynamic non-responders to pharmacological therapy.
Dig. Liver Dis. 44(1) , 55-60, (2012) It is unknown which is the best therapy to treat haemodynamic non-responders to pharmacological therapy after variceal bleeding.To evaluate the efficacy of adding banding ligation to drugs to prevent variceal rebleeding in haemodynamic non-responders to drugs... |