WAY-100635 (maleate salt)
WAY-100635 (maleate salt) structure
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Common Name | WAY-100635 (maleate salt) | ||
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| CAS Number | 634908-75-1 | Molecular Weight | 538.635 | |
| Density | N/A | Boiling Point | 594.8ºC at 760 mmHg | |
| Molecular Formula | C29H38N4O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 313.5ºC | |
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LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor.
Psychopharmacology 208(2) , 179-89, (2010) Compounds that activate the 5-HT(2A) receptor, such as lysergic acid diethylamide (LSD), act as hallucinogens in humans. One notable exception is the LSD congener lisuride, which does not have hallucinogenic effects in humans even though it is a potent 5-HT(2... |
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The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes.
Eur. J. Pharmacol. 288 , 173, (1995) The tritiated derivative of the novel silent 5-HT1A receptor antagonist WAY 100635 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide] was tested as a potential radioligand of 5-HT1A receptors in the rat brain. Binding ass... |
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Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist.
Behav. Brain Res. 73 , 337, (1996) Although considerable progress has been made in characterising the 5-HT1A receptor using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A receptor function have been hindered by the lack of highly selective antagonists. The t... |
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A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.
Eur. J. Pharmacol. 281 , 81, (1995) WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride) is an achiral phenylpiperazine derivative that binds with high affinity and selectivity to the 5-HT1A receptor. WAY-100635 displaced specific b... |
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In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors.
Eur. Neuropsychopharmacol. 9 , 15-19, (1999) The receptor-mediated control of brain monoamine synthesis was used to examine the in vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, S(-)-UH-301 and WAY-100,635. The rate of monoamine synthesis was estimated by measuring the accumulation ... |
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Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
Front. Pharmacol. 4 , 97, (2013) Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as anxiety dis... |