n-acetyl-n-acetoxy-4-chlorobenzenesulfonamide
n-acetyl-n-acetoxy-4-chlorobenzenesulfonamide structure
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Common Name | n-acetyl-n-acetoxy-4-chlorobenzenesulfonamide | ||
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| CAS Number | 142867-52-5 | Molecular Weight | 291.70800 | |
| Density | 1.454 g/cm3 | Boiling Point | 401.4ºC at 760 mmHg | |
| Molecular Formula | C10H10ClNO5S | Melting Point | 119-122ºC | |
| MSDS | Chinese USA | Flash Point | 196.6ºC | |
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Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase.
J. Med. Chem. 35 , 3648, (1992) In the preceding paper, analogs of chlorpropamide with an OMe substituent on the sulfonamide nitrogen were shown to inhibit aldehyde dehydrogenase (AlDH), and it was postulated that these compounds were bioactivated by O-demethylation to release nitroxyl (HN ... |
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N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties.
Biochem. Biophys. Res. Commun. 187 , 1367, (1992) N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation ... |
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