SB202190 (FHPI)
SB202190 (FHPI) structure
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Common Name | SB202190 (FHPI) | ||
|---|---|---|---|---|
| CAS Number | 152121-30-7 | Molecular Weight | 331.343 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 565.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H14FN3O | Melting Point | 240-243℃ | |
| MSDS | USA | Flash Point | 295.9±30.1 °C | |
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Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro.
Acta Pharmacol. Sin. 36(4) , 517-27, (2015) To investigate the effects of physalin B insolated from Physalis divericata on human colon cancer cells in vitro and its anticancer mechanisms.Human HCT116 colon cancer cell line was tested. Cell viability and apoptosis were detected, and relevant proteins we... |
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Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes.
Stem Cells Dev. 23(20) , 2435-42, (2014) Adhesion of Plasmodium falciparum-infected red blood cells (iRBC) to human erythrocytes (i.e. rosetting) is associated with severe malaria. Rosetting results from interactions between a subset of variant PfEMP1 (Plasmodium falciparum erythrocyte membrane prot... |
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Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells.
J. Immunol. 193(12) , 6135-43, (2014) Recent studies suggest a role for autophagy in the secretion of IL-1 cytokines regulating the development of inflammatory diseases. The antimalarial drug and autophagy/lysosome inhibitor chloroquine (CHQ) is considered as potential trigger of drug-induced or ... |
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Transient neuroprotection by SRY upregulation in dopamine cells following injury in males.
Endocrinology 155(7) , 2602-12, (2014) Emerging evidence suggest sex-specific regulation of dopamine neurons may underlie susceptibility of males to disorders such as Parkinson's disease (PD). In healthy male dopamine neurons, the Y-chromosome gene product, the sex-determining region on the Y chro... |
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Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).
J. Biol. Chem. 286(38) , 33335-44, (2011) Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an unidentified site leads to shedding of i... |
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Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells.
Eur. J. Clin. Invest. 36(8) , 588-96, (2006) The molecular mechanisms underlying the mitogenic effect of ferulic acid (FA), an active compound derived from Angelica sinensis, have never been elucidated. It was the aim of this study to investigate the proliferative effect of FA on human breast cancer cel... |
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A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.
J. Biol. Chem. , 32288-97, (2007) Endothelial cell apoptosis is associated with vascular injury and predisposes to atherogenesis. Endothelial cells express anti-apoptotic genes including Bcl-2, Bcl-XL and survivin, which also contribute to angiogenesis and vascular remodeling. We report a cen... |
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Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells.
J. Biol. Chem. , 31900-8, (2007) Ethanol metabolism plays a central role in activating the mitogen-activated protein kinase (MAPK) cascade leading to inflammation and apoptosis. Sustained activation of c-Jun N-terminal kinase (JNK), one of the MAPKs, has been shown to induce apoptosis in hep... |
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Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.
J. Thorac. Cardiovasc. Surg. 285 , 9067-76, (2010) Wild-type p53-induced phosphatase (Wip1) is induced by p53 in response to stress, which results in the dephosphorylation of proteins (i.e. p38 MAPK, p53, and uracil DNA glycosylase) involved in DNA repair and cell cycle checkpoint pathways. p38 MAPK-p53 signa... |
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Structural inference of native and partially folded RNA by high-throughput contact mapping.
Proc. Natl. Acad. Sci. U. S. A. , 4144-9, (2008) The biological behaviors of ribozymes, riboswitches, and numerous other functional RNA molecules are critically dependent on their tertiary folding and their ability to sample multiple functional states. The conformational heterogeneity and partially folded n... |