GR 82334
GR 82334 structure
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Common Name | GR 82334 | ||
|---|---|---|---|---|
| CAS Number | 129623-01-4 | Molecular Weight | 1386.55000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C69H91N15O16 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Effect of tachykinins on ascending and descending reflex pathway in rat small intestine.
Acta Pharmacol. Sin. 23(4) , 289-95, (2002) To examine the effect of tachykinins on the ascending reflex pathway in rat small intestine, we used different selective neurokinin (NK) receptor antagonists (RA): a) NK1-RA: GR-82334 and CP-96.345, b) NK2-RA: MEN-10.376 and L-659.877. The aim was further to ... |
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Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes.
Br. J. Pharmacol. 138(7) , 1233-43, (2003) 1. Neurokinins contribute to the neural regulation of gastrointestinal (GI) smooth muscles. We studied responses of murine colonic smooth muscle cells to substance P (SP) and NK(1) and NK(2) agonists using confocal microscopy and the patch clamp technique. 2.... |
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Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.
Naunyn Schmiedebergs Arch. Pharmacol. 370(1) , 35-45, (2004) Two tachykinin peptides, bufokinin and Xenopus neurokinin A (X-NKA) were recently isolated from Xenopus laevis. In this study we investigated the tachykinin receptors in the Xenopus gastrointestinal tract. In functional studies using stomach circular muscle s... |
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Substance P sensitizes P2X3 in nociceptive trigeminal neurons.
J. Dent. Res. 89(10) , 1154-9, (2010) Peripheral inflammation produces pain hypersensitivity by sensitizing nociceptors. Potentiation of P2X3 receptor activity in nociceptors may play an important role in this peripheral sensitization. However, we do not fully understand how P2X3 activity is elev... |
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Increased ganglionic responses to substance P in hypertensive rats due to upregulation of NK(1) receptors.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 279(5) , R1685-94, (2000) Intravenous injection of substance P (SP) increases renal nerve firing and heart rate in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) by stimulating sympathetic ganglia. Blood pressure is increased in SHRs but lowered in WKYs. This stud... |
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Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct.
Naunyn Schmiedebergs Arch. Pharmacol. 360(3) , 344-53, (1999) In functional experiments, we have investigated the effect exerted by neurotransmitters released from capsaicin-sensitive primary afferent nerve terminals in the isolated guinea-pig common bile duct. In resting preparations, capsaicin (0.1 microM) produced a ... |
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Intra-articular administration of tachykinin NK₁ receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis.
Eur. J. Pharmacol. 668(1-2) , 163-8, (2011) Persistent pain associated with inflammatory arthritis is an aggravating factor that decreases patients' quality of life. Current therapies for joint pain have limited effectiveness and produce unwanted negative side effects. Although the involvement of subst... |
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Evidence for the involvement of ATP, but not of VIP/PACAP or nitric oxide, in the excitatory effect of capsaicin in the small intestine.
Eur. J. Pharmacol. 392(3) , 183-8, (2000) The contractile effect of capsaicin in the guinea-pig small intestine involves an activation of enteric cholinergic neurons. Our present data show that the P(2) purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS, 30 microM) ... |
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Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.
FEBS Lett. 583(12) , 2148-53, (2009) The effects of the sensory neurotransmitter substance P on the expression of tight junction proteins and on barrier function in human corneal epithelial cells were investigated. The expression of ZO-1, but not that of occludin or claudin-1, was increased by s... |
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Substance P and neurokinin 1 receptors as potential therapeutic targets in children with OSA.
Chest 145(5) , 1039-45, (2014) Increased substance P (SP) levels and abundant expression of neurokinin (NK) 1 receptor in adenotonsillar tissues of children with OSA but not recurrent tonsillar infection (RI) suggest that NK1 antagonists could be useful in treating OSA.The effects of SP an... |