Olvanil
Olvanil structure
|
Common Name | Olvanil | ||
|---|---|---|---|---|
| CAS Number | 58493-49-5 | Molecular Weight | 417.62 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 596.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H43NO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 314.3±30.1 °C | |
|
Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.
Life Sci. 92(6-7) , 368-78, (2013) Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of the present study was to know whether various vanilloids have... |
|
|
Identification of drug modulators targeting gene-dosage disease CMT1A.
ACS Chem. Biol. 7(7) , 1205-13, (2012) The structural integrity of myelin formed by Schwann cells in the peripheral nervous system (PNS) is required for proper nerve conduction and is dependent on adequate expression of myelin genes including peripheral myelin protein 22 (PMP22). Consequently, exc... |
|
|
Activation of recombinant human TRPV1 receptors expressed in SH-SY5Y human neuroblastoma cells increases [Ca(2+)](i), initiates neurotransmitter release and promotes delayed cell death.
J. Neurochem. 102(3) , 801-11, (2007) The transient receptor potential (TRP) vanilloid receptor subtype 1 (TRPV1) is a ligand-gated, Ca(2+)-permeable ion channel in the TRP superfamily of channels. We report the establishment of the first neuronal model expressing recombinant human TRPV1 (SH-SY5Y... |
|
|
Olvanil, a non-pungent vanilloid enhances the gastrointestinal toxicity of cisplatin in the ferret.
Toxicol. Lett. 192(3) , 402-7, (2010) Pungent transient receptor potential vanilloid (TRPV1) channel activators have been shown to have broad inhibitory anti-emetic activity against centrally- and peripherally acting challenges but only at doses that have adverse effects on the cardiovascular sys... |
|
|
Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons.
Neuroscience 141(1) , 407-19, (2006) Olvanil ((N-vanillyl)-9-oleamide), a non-pungent transient receptor potential vanilloid type 1 agonist, desensitizes nociceptors and alleviates pain. But its molecular targets and signaling mechanisms are little known. Calcium influx through voltage-activated... |
|
|
Olvanil acts on transient receptor potential vanilloid channel 1 and cannabinoid receptors to modulate neuronal transmission in the trigeminovascular system.
Pain 153(11) , 2226-32, (2012) The transient receptor potential vanilloid channel 1 (TRPV1) is a nociceptive transducer located on nociceptive neurons. TRPV1 channels located on peripheral neurons mainly transduce the sense of heat and are also activated by low pH or capsaicin. The role of... |
|
|
Effect of olvanil and anandamide on vagal C-fiber subtypes in guinea pig lung.
Br. J. Pharmacol. 146(4) , 596-603, (2005) Certain fatty acid amides such as anandamide (AEA) and olvanil are agonists for the transient receptor potential, vanilloid-1 (TRPV1) receptor, but have been found to activate TRPV1-containing C-fibers in some tissues but not others. We used extracellular rec... |
|
|
Vanilloid (subtype 1) receptor-modulatory drugs inhibit [3H]batrachotoxinin-A 20-alpha-benzoate binding to Na+ channels.
Basic Clin Pharmacol Toxicol. 100(2) , 91-5, (2007) This investigation was conducted to provide further insight into the effects of vanilloid (subtype 1) receptor (VR1) drugs at voltage-gated sodium channels and examine the potential of this interaction to influence release of neurotransmitters from synaptosom... |
|
|
TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons.
Biochem. Biophys. Res. Commun. 410(4) , 841-5, (2011) We examined the effects of TRPV1 agonists olvanil and piperine on glutamatergic spontaneous excitatory transmission in the substantia gelatinosa (SG) neurons of adult rat spinal cord slices with the whole-cell patch-clamp technique. Bath-applied olvanil did n... |
|
|
Effect of olvanil on the afferent and efferent function of capsaicin-sensitive C-fibers in guinea pig airways.
Eur. J. Pharmacol. 471(3) , 205-11, (2003) The aim of the present study was to examine the ability of the nonpungent vanilloid VR1 receptor agonist, olvanil, to activate the afferent and efferent function of capsaicin-sensitive C-fibers in guinea pig airways. We found that while capsaicin (10 nM-10 mi... |