IB-MECA
IB-MECA structure
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Common Name | IB-MECA | ||
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| CAS Number | 152918-18-8 | Molecular Weight | 510.286 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H19IN6O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Equilibrium and kinetic selectivity profiling on the human adenosine receptors.
Biochem. Pharmacol. 105 , 34-41, (2016) Classical evaluation of target selectivity is usually undertaken by measuring the binding affinity of lead compounds against a number of potential targets under equilibrium conditions, without considering the kinetics of the ligand-receptor interaction. In th... |
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Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.
J. Thorac. Cardiovasc. Surg. 140(2) , 440-6, (2010) Adenosine and the activation of specific adenosine receptors are implicated in the attenuation of inflammation and organ ischemia-reperfusion injury. We hypothesized that activation of A(1), A(2A), or A(3) adenosine receptors would provide protection against ... |
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Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Am. J. Physiol. Gastrointest. Liver Physiol. 297(6) , G1147-62, (2009) We tested the novel hypothesis that endogenous adenosine (eADO) activates low-affinity A3 receptors in a model of neurogenic diarrhea in the guinea pig colon. Dimaprit activation of H2 receptors was used to trigger a cyclic coordinated response of contraction... |
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A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.
FEBS Lett. 336 , 57-60, (1993) The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse brain were examined. Low levels of A3 adenosine receptors were... |
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The effects of adenosine A3 receptor stimulation on seizures in mice.
Eur. J. Pharmacol. 275 , 23-29, (1995) We have previously shown that acute preischemic adenosine A3 receptor stimulation results in an increased postischemic damage, while chronic stimulation of this receptor diminishes it. Since several pathophysiological phenomena are common for both ischemia an... |
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Activation of adenosine A(3) receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells.
Physiol. Res. 58(2) , 247-52, (2009) Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage... |
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IB-MECA, an adenosine A(3) receptor agonist, does not influence survival of lethally γ-irradiated mice.
Physiol. Res. 61(6) , 649-54, (2012) In our previous studies, IB-MECA, an adenosine A(3) receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regenerati... |
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Induction of apoptosis by A3 adenosine receptor agonist N-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide in human leukaemia cells: a possible involvement of intracellular mechanism.
Acta Physiol. (Oxf.) 199(2) , 171-9, (2010) The sensitivity of cancer cells which exhibit multi-drug resistance phenotype to A3 adenosine receptor (A3AR) agonist N(6)-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide (IB-MECA) was studied.To establish direct relationship between P-glycoprotein (P-gp, ABC... |
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Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level.
J. Rheumatol. 34(1) , 20-6, (2007) A3 adenosine receptor (A3AR) upregulation has been found in cells of synovial tissue and in peripheral blood mononuclear cells (PBMC) of rats with adjuvant-induced arthritis. We investigated A3AR levels in PBMC of patients with rheumatoid arthritis (RA) and i... |
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Activation of adenosine A(3) receptors supports hematopoiesis-stimulating effects of granulocyte colony-stimulating factor in sublethally irradiated mice.
Int. J. Radiat. Biol. 86(8) , 649-56, (2010) Research areas of 'post-exposure treatment' and 'cytokines and growth factors' have top priority among studies aimed at radiological nuclear threat countermeasures. The experiments were aimed at testing the ability of N(6)-(3-iodobenzyl)adenosine-5'-N-methylu... |