Pepstatin
Pepstatin structure
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Common Name | Pepstatin | ||
|---|---|---|---|---|
| CAS Number | 26305-03-3 | Molecular Weight | 685.892 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 997.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C34H63N5O9 | Melting Point | 233 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 557.1±34.3 °C | |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
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Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes.
Autophagy 10(9) , 1637-51, (2014) Autophagy is a lysosomal degradative pathway that has diverse physiological functions and plays crucial roles in several viral infections. Here we examine the role of autophagy in the life cycle of JEV, a neurotropic flavivirus. JEV infection leads to inducti... |
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Comparison of arterial pressure and plasma ANG II responses to three methods of subcutaneous ANG II administration.
Am. J. Physiol. Heart Circ. Physiol. 307(5) , H670-9, (2014) Angiotensin II (ANG II)-induced hypertension is a commonly studied model of experimental hypertension, particularly in rodents, and is often generated by subcutaneous delivery of ANG II using Alzet osmotic minipumps chronically implanted under the skin. We ha... |
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ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid.
PLoS ONE 9(5) , e96418, (2014) Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and in vitro. However, the underlying molecular mechanisms remain unclear. In this study, we found that GA could initiate autophagy in colorectal cancer... |
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Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.
Biol. Reprod. 80 , 286-94, (2008) A universal response to cellular stress is the expression of transformation-related protein 53 (TRP53). This transcription factor reduces cell proliferation and/or survival and is classed as a tumour suppressor protein. Several stresses (including culture) ca... |
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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Proc. Natl. Acad. Sci. U. S. A. 105 , 3374-3379, (2008) We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. In particular, transient increased expression of Sirt1 is sufficient to stimulate basal rates of autophagy. In addition, we show that Sirt1(-/-) mouse embryonic fibr... |
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Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis.
Mol. Biol. Cell 20 , 4153-61, (2009) Annexin A2 is involved in multiple cellular processes, including cell survival, growth, division, and differentiation. A lack of annexin A2 makes cells more sensitive to apoptotic stimuli. Here, we demonstrate a potential mechanism for apoptotic stimuli-induc... |
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Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation.
BMC Biol. 6 , 8, (2008) The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrPC) to an alternatively folded isoform (PrPSc). The accumulation of PrPSc within the brain lead... |
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Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.
Biochem. Pharmacol. 49 , 1236-47, (2010) Usher syndrome is the major cause of deaf/blindness in the world. It is a genetic heterogeneous disorder, with nine genes already identified as causative for the disease. We noted expression of all known Usher proteins in bovine tracheal epithelial cells and ... |
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RaPID: an aptamer-based mRNA affinity purification technique for the identification of RNA and protein factors present in ribonucleoprotein complexes.
Methods Mol. Biol. 714 , 387-406, (2011) RNA metabolism involves regulatory processes, such as transcription, splicing, nuclear export, transport and localization, association with sites of RNA modification, silencing and decay, and necessitates a wide variety of diverse RNA-interacting proteins. Th... |