Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt
Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt structure
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Common Name | Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt | ||
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| CAS Number | 143113-45-5 | Molecular Weight | 2006.32 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 2125.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C96H140N20O25S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 1239.5±34.3 °C | |
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Endothelin-1 stimulates aldosterone synthesis in Conn's adenomas via both A and B receptors coupled with the protein kinase C- and cyclooxygenase-dependent signaling pathways.
J. Investig. Med. 48(5) , 343-50, (2000) The mechanisms and factors leading to enhanced aldosterone secretion and ultimately to neoplastic transformation of the adrenal cortex are poorly defined. Angiotensin-II (Ang-II) and endothelin-1 (ET-1) have emerged as likely candidates among potential aldost... |
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Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859.
J. Hypertens. 18(12) , 1815-23, (2000) To examine the chronic effects of a newly synthesized, potent and selective endothelin (ET) ETA receptor antagonist, J-1 05859, on mortality in salt-loaded Dahl salt-sensitive (DS) rats and to confirm the potential of this compound as an ETA antagonistVehicle... |
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Mechanisms involved in the effects of endothelin-1 in pig prostatic small arteries.
Eur. J. Pharmacol. 640(1-3) , 190-6, (2010) Since endothelin-1 (ET-1) is involved in prostatic disorders, the current study investigated the mechanisms underlying the ET-1-induced effects in pig prostatic small arteries. The experiments were performed in rings mounted in microvascular myographs contain... |
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Mechanisms transducing the aldosterone secretagogue signal of endothelins in the human adrenal cortex.
Peptides 23(3) , 561-6, (2002) Evidence has been provided that the 21-amino acid hypertensive peptide endothelin (ET)-1 exerts a potent secretagogue effect on human adrenocortical zona glomerulosa (ZG), acting through two receptor subtypes, called ET(A) and ET(B), the signaling mechanism(s... |
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Imaging endothelin ET(B) receptors using [18F]-BQ3020: in vitro characterization and positron emission tomography (microPET).
Exp. Biol. Med. (Maywood.) 231(6) , 736-40, (2006) The endothelin (ET) receptor system has been shown to play a role in a number of vascular diseases. We have synthesized 18F-and 11C-labeled radioligands to enable in vivo imaging of the fundamental processes involved in ET receptor pharmacology in normal and ... |
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Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck.
Neurourol. Urodyn. 31(5) , 688-94, (2012) The involvement of endothelin receptors in the contraction of the lower urinary tract smooth muscle is well established. There is scarce information, however, about endothelin receptors mediating relaxation of the bladder outlet region. The current study inve... |
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Inhibitory effect of ETB receptor on Na(+)-K(+) ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells.
Hypertens. Res. 32(10) , 846-52, (2009) The kidney is important in the long-term regulation of blood pressure and sodium homeostasis. Stimulation of ETB receptors in the kidney increases sodium excretion, in part, by decreasing sodium transport in the medullary thick ascending limb of Henle and in ... |
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Syntheses of the first endothelin-A- and -B-selective radioligands for positron emission tomography.
J. Cardiovasc. Pharmacol. 36(5 Suppl 1) , S58-60, (2000) We have synthesized two potential positron emission tomography (PET) radioligands for the endothelin (ET) receptor. [11C]-PD156707 was produced by O-methylation of PD169390 using [11C]iodomethane. Radiochemical conversions of the order of 74 +/- 3.2% (n = 8) ... |
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Down-regulation of ETA receptors in ETB receptor-deficient mice.
J. Cardiovasc. Pharmacol. 44 Suppl 1 , S276-8, (2004) Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-defic... |
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Buffering action of endogenous nitric oxide on the adrenocortical secretagogue effect of endothelins in the rat.
Int. J. Mol. Med. 7(1) , 55-9, (2001) The secretagogue effect of endothelins (ETs) on the rat adrenal cortex is mediated by the ETB receptor. ETB receptors are coupled with nitric oxide (NO) synthase (NOS), and NO is known to inhibit steroid-hormone secretion from adrenal cortex. We investigated ... |