Rottlerin
Rottlerin structure
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Common Name | Rottlerin | ||
|---|---|---|---|---|
| CAS Number | 82-08-6 | Molecular Weight | 516.539 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 800.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C30H28O8 | Melting Point | 200 °C | |
| MSDS | Chinese USA | Flash Point | 266.0±27.8 °C | |
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Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ.
J. Biol. Chem. 291 , 3184-96, (2016) Pro-inflammatory cytokines contribute to the decline in islet function during the development of diabetes. Cytokines can disrupt insulin secretion and calcium dynamics; however, the mechanisms underlying this are poorly understood. Connexin36 gap junctions co... |
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PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.
Biochim. Biophys. Acta 1853 , 1586-95, (2015) PKC activation by combining TPA with sodium butyrate (T/B) represents the most effective and widely used strategy to induce the Epstein-Barr virus (EBV) lytic cycle. The results obtained in this study show that novel PKCθ is involved in such process and that ... |
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Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse.
J. Pharmacol. Exp. Ther. 351(1) , 77-86, (2014) Contractile responses in small intrarenal arteries are associated with diabetic nephropathy. However, the mechanisms that induce and maintain altered small vessel contraction are not clearly understood. To further understand intrarenal artery dysfunction in d... |
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Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression.
Int. Immunopharmacol. 29 , 15-20, (2015) Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complication... |
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Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells.
PLoS ONE 7(11) , e50297, (2012) Low-density lipoprotein (LDL) is subjected to glycoxidation in diabetes, and a novel signalling mechanism by which glycoxidised LDL functions in glomerular mesangial cells remains to be ascertained.We performed gene expression analysis in mouse glomerular mes... |
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The involvement of selected membrane transport mechanisms in the cellular uptake of (177)Lu-labeled bombesin, somatostatin and gastrin analogues.
Nucl. Med. Biol. 42(1) , 1-7, (2014) Radiolabeled receptor-targeting peptides are a useful tool for the diagnostic imaging and radiotherapy of some malignancies. However, the retention of radioactivity in the kidney may result in renal radiotoxic injury. This study seeks to evaluate the role of ... |
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Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.
Biochemistry 48 , 7732-45, (2009) Inclusions comprised of fibrils of the microtubule- (MT-) associated protein tau are found in the brains of those with Alzheimer's disease (AD) and other neurodegenerative tauopathies. The pathology that is observed in these diseases is believed to result fro... |
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Semisynthesis of mallotus B from rottlerin: evaluation of cytotoxicity and apoptosis-inducing activity.
J. Nat. Prod. 76(9) , 1724-30, (2013) Mallotus B (2d) is a prenylated dimeric phloroglucinol compound isolated from Mallotus philippensis. There have been no reports on the synthesis or biological activity of this compound. In the present paper, a semisynthetic preparation of mallotus B is report... |
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Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
J. Biol. Chem. 287(31) , 26168-76, (2012) Endothelial nitric-oxide synthase (eNOS) utilizes l-arginine as its principal substrate, converting it to l-citrulline and nitric oxide (NO). l-Citrulline is recycled to l-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate lyase, p... |
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PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy.
J. Cell. Biochem. 117 , 730-40, (2016) Protein kinase C (PKC) is a family of serine/threonine kinases that regulate diverse cellular functions including cell death, proliferation, and survival. Recent studies have reported that PKCδ, are involved in apoptosis or autophagy induction. In the present... |