SL-327
SL-327 structure
|
Common Name | SL-327 | ||
|---|---|---|---|---|
| CAS Number | 305350-87-2 | Molecular Weight | 335.347 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 512.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12F3N3S | Melting Point | 127-128.2ºC | |
| MSDS | Chinese USA | Flash Point | 263.8±30.1 °C | |
|
Oncogenic Ras inhibits IRF1 to promote viral oncolysis.
Oncogene 34 , 3985-93, (2015) Oncolytic viruses exploit common molecular changes in cancer cells, which are not present in normal cells, to target and kill cancer cells. Ras transformation and defects in type I interferon (IFN)-mediated antiviral responses are known to be the major mechan... |
|
|
Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits.
Hippocampus 24(12) , 1466-81, (2014) The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retrieval of memories. Although much less characterized, epileptif... |
|
|
Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.
Alcohol. Clin. Exp. Res. 39(3) , 463-75, (2015) Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes alcohol dependence and addiction. The transition from binge alcohol drinking to alcohol addiction likely involves mechanisms of synaptic plasticity and learning ... |
|
|
GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity.
Neurochem. Res. 39(11) , 2262-75, (2014) Ganglioside GM1 at micro- and nanomolar concentrations was shown to increase the viability of pheochromocytoma PC12 cells exposed to hydrogen peroxide and diminish the accumulation of reactive oxygen species and oxidative inactivation of Na(+),K(+)-ATPase, th... |
|
|
Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.
Cell Death Dis. 5 , e1296, (2014) Acetylation homeostasis is thought to play a role in amyotrophic lateral sclerosis, and treatment with inhibitors of histone deacetylases has been considered a potential and attractive therapeutic approach, despite the lack of a thorough study of this class o... |
|
|
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
PLoS ONE 9(9) , e106316, (2014) Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces slow excitatory responses through activation of transient receptor potential canonical (TRPC) channels. GABAergic cerebellar molecular layer interneurons (MLIs... |
|
|
Activin B promotes BMSC-mediated cutaneous wound healing by regulating cell migration via the JNK-ERK signaling pathway.
Cell. Transplant. 23(9) , 1061-73, (2014) Bone marrow-derived mesenchymal stem cells (BMSCs) are able to differentiate into various types of skin cells and participate in skin regeneration and repair. Activin signaling can regulate wound healing and reepithelialization. The present study assessed the... |
|
|
Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells.
Stem Cell Res. 12(1) , 119-31, (2014) Reactive oxygen species (ROS) are involved in various aspects of cancer cell biology, yet their role in cancer stem cells (CSCs) has been poorly understood. In particular, it still remains unclear whether and how ROS control the self-renewal/differentiation p... |
|
|
Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain.
Sci. Rep. 6 , 21859, (2016) In animal models, neonatal exposure to general anesthetics significantly increased neuronal apoptosis with subsequent behavioral deficits in adulthood. Although the underlying mechanism is largely unknown, involvement of extracellular signal-regulated kinases... |
|
|
DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells.
Biol. Pharm. Bull. 38(2) , 169-78, (2015) In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response eleme... |