[Sar9,Met(O2)11]-Substance P TFA
![[Sar9,Met(O2)11]-Substance P TFA Structure](https://image.chemsrc.com/caspic/198/110880-55-2.png)
[Sar9,Met(O2)11]-Substance P TFA structure
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Common Name | [Sar9,Met(O2)11]-Substance P TFA | ||
|---|---|---|---|---|
| CAS Number | 110880-55-2 | Molecular Weight | 1393.655 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C64H100N18O15S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies.
J. Physiol. Pharmacol. 58(4) , 829-43, (2007) The aim of the present study was to investigate the influence of melatonin on vasopressin (AVP) release from the rat hypothalamo-neurohypophysial (H-NH) system, both in vivo and in vitro, possibly modified by the peptide NK-1 and/or NK-2 receptor agonists and... |
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Differential role of neurokinin receptors in human lymphocyte and monocyte chemotaxis.
Regul. Pept. 96 , 17-21, (2000) The precise nature of neurokin receptor involvement in human immune cell chemotaxis is unclear. This study therefore sought to directly compare the chemotactic effects of neurokinins on human T lymphocytes and monocytes. Substance P was found to have a simila... |
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Neurokinin receptor modulation of respiratory activity in the rabbit.
Eur. J. Neurosci. 27(12) , 3233-43, (2008) The respiratory role of neurokinin (NK) receptors was investigated in alpha-chloralose-urethane-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nL) of NK receptor agonists and antagonists. Mi... |
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Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.
Neuro Endocrinol. Lett. 26(4) , 367-72, (2005) Present experiments were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on vasopressin (AVP) secretion from the rat hypo... |
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Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes.
Br. J. Pharmacol. 138(7) , 1233-43, (2003) 1. Neurokinins contribute to the neural regulation of gastrointestinal (GI) smooth muscles. We studied responses of murine colonic smooth muscle cells to substance P (SP) and NK(1) and NK(2) agonists using confocal microscopy and the patch clamp technique. 2.... |
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Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin.
Naunyn Schmiedebergs Arch. Pharmacol. 370(1) , 35-45, (2004) Two tachykinin peptides, bufokinin and Xenopus neurokinin A (X-NKA) were recently isolated from Xenopus laevis. In this study we investigated the tachykinin receptors in the Xenopus gastrointestinal tract. In functional studies using stomach circular muscle s... |
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The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.
J. Neurochem. 111(3) , 656-68, (2009) In a previous study we showed that pharmacological blockade of the neurokinin-1 receptors attenuated the methamphetamine (METH)-induced toxicity of the striatal dopamine terminals. In the present study we examined the role of the neurokinin-1 receptors on the... |
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Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea.
J. Physiol. 575(Pt 3) , 869-85, (2006) In the present study, we examined the role of the neurokinin-1 receptor (NK1R) in the modulation of respiratory rhythm in a functionally identified bradypnoeic region of the ventral respiratory group (VRG) in the in situ arterially perfused juvenile rat prepa... |
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A model of organotypic rat spinal slice culture and biolistic transfection to elucidate factors that drive the preprotachykinin-A promoter.
Brain Res. Brain Res. Rev. 46(2) , 191-203, (2004) The tachykinin substance P (SP) is a neuropeptide that is expressed in some nociceptive primary sensory afferents and in discrete populations of spinal cord neurons. Expression of spinal SP and the preprotachykinin-A (PPT-A) gene that encodes SP exhibits plas... |
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Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.
Eur. J. Pharmacol. 570(1-3) , 196-202, (2007) The present study examined the effects induced by endogenous and exogenous activation of NK(1) and NK(2) receptors on the mechanical activity of mouse proximal colon. Experiments were performed in vitro recording the changes in intraluminal pressure from isol... |