Leupeptin hemisulfate salt
Leupeptin hemisulfate salt structure
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Common Name | Leupeptin hemisulfate salt | ||
|---|---|---|---|---|
| CAS Number | 103476-89-7 | Molecular Weight | 475.59 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H38N6O4.1/2H2SO4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells.
Int. Immunopharmacol. 24(2) , 369-76, (2015) The development of agents that can modulate microglial activation has been suggested as one potential strategy for the treatment or prevention of neurodegenerative diseases. Among these agents, resveratrol, with its anti-inflammatory action, has been describe... |
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Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.
Pain 156 , 2295-309, (2015) Elevated nerve growth factor (NGF) in the contralateral dorsal root ganglion (DRG) mediates mirror-image pain after peripheral nerve injury, but the underlying mechanism remains unclear. Using intrathecal injection of NGF antibodies, we found that NGF is requ... |
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Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase.
J. Biol. Chem. 290 , 27248-60, (2015) Porphyromonas gingivalis is a peptide-fermenting asaccharolytic periodontal pathogen. Its genome contains several genes encoding cysteine peptidases other than gingipains. One of these genes (PG1055) encodes a protein called Tpr (thiol protease) that has sequ... |
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ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.
Cytokine 71(2) , 238-45, (2015) Interleukin (IL)-1 is one of the most evolutionarily conserved cytokines and plays an essential role in the regulation of innate immunity. IL-1 binds to two different receptors, IL-1R1 and IL-1R2, which share approximately 28% amino acid homology. IL-1R1 cont... |
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An activated sympathetic nervous system affects white adipocyte differentiation and lipolysis in a rat model of Parkinson's disease.
J. Neurosci. Res. 93(2) , 350-60, (2014) Weight loss is an important nonmotor symptom associated with Parkinson's disease (PD). However, the cellular factors responsible for PD-induced weight loss remain unclear. Because the sympathetic nervous system plays an important role in lipid metabolism and ... |
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Annexin VI-mediated loss of spectrin during coated pit budding is coupled to delivery of LDL to lysosomes.
J. Cell Biol. 142 , 937-47, (1998) Previously we reported that annexin VI is required for the budding of clathrin-coated pits from human fibroblast plasma membranes in vitro. Here we show that annexin VI bound to the NH2-terminal 28-kD portion of membrane spectrin is as effective as cytosolic ... |
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Expression, purification and use of recombinant annexin V for the detection of apoptotic cells.
Nat. Protoc. 4 , 1383-95, (2009) Apoptosis is a mode of programmed cell death that is widely used to eliminate cells during development, tissue homeostasis, infection or in response to injury. Alterations to the plasma membranes of apoptotic cells trigger recognition and engulfment of such c... |
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PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction.
Hum. Mol. Genet. 24 , 7227-40, (2015) Gene mutations, mostly segregating with a dominant mode of inheritance, are important causes of dilated cardiomyopathy (DCM), a disease characterized by enlarged ventricular dimensions, impaired cardiac function, heart failure and high risk of death. Another ... |
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Structures and activities of protease inhibitors of microbial origin.
Meth. Enzymol. 45 , 678, (1976)
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Leupeptins, new protease inhibitors from Actinomycetes.
J. Antibiot. 22 , 283, (1969)
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